Abstract
Survival analysis by tumor response of nivolumab treatment in previously treated advanced gastric cancer from the DELIVER trial (JACCRO GC-08).
Author
Yu Sunakawa
Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki, Japan
info_outline
Yu Sunakawa, Yasuhiro Sakamoto, Ryohei Kawabata, Atsushi Ishiguro, Yusuke Akamaru, Yosuke Kito, Masazumi Takahashi, Jin Matsuyama, Hiroshi Yabusaki, Akitaka Makiyama, Takahisa Suzuki, Masahiro Tsuda, Hisateru Yasui, Jun Hihara, Atsushi Takeno, Eisuke Inoue, Wataru Ichikawa, Masashi Fujii
Full text
Authors
Yu Sunakawa
Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki, Japan
info_outline
Yu Sunakawa, Yasuhiro Sakamoto, Ryohei Kawabata, Atsushi Ishiguro, Yusuke Akamaru, Yosuke Kito, Masazumi Takahashi, Jin Matsuyama, Hiroshi Yabusaki, Akitaka Makiyama, Takahisa Suzuki, Masahiro Tsuda, Hisateru Yasui, Jun Hihara, Atsushi Takeno, Eisuke Inoue, Wataru Ichikawa, Masashi Fujii
Organizations
Department of Clinical Oncology, St. Marianna University School of Medicine, Kawasaki, Japan, Department of Medical Oncology, Osaki Citizen Hospital, Osaki, Japan, Department of Surgery, Sakai City Medical Center, Sakai, Japan, Department of Medical Oncology, Teine Keijinkai Hospital, Sapporo, Japan, Department of Gastrointestinal Surgery, Ikeda City Hospital, Ikeda, Japan, Department of Medical Oncology, Ishikawa Prefectural Central Hospital, Ishikawa, Japan, Division of Gastroenterological Surgery, Yokohama Municipal Citizen's Hospital, Yokohama, Japan, Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Higashi Osaka City, Japan, Department of Gastroenterological Surgery, Niigata Cancer Center Hospital, Niigata, Japan, Cancer Center, Gifu University Hospital, Gifu, Japan, Department of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan, Department of Gastroenterological Oncology, Hyogo Cancer Center, Akashi, Japan, Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, Japan, Department of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan, Department of Surgery, Kansai Rosai Hospital, Amagasaki, Japan, Showa University Research Administration Center, Showa University, Tokyo, Japan, Division of Medical Oncology, Showa University Fujigaoka Hospital, Yokohama, Japan, Japan Clinical Cancer Research Organization, Tokyo, Japan
Abstract Disclosures
Research Funding
Pharmaceutical/Biotech Company
Ono Pharmaceutical and Bristol-Myers Squibb
Background:
We conducted a prospective observational study, DELIVER trial (UMIN000030850), to evaluate the real-world effectiveness of nivolumab monotherapy in previously treated advanced gastric cancer (GC) and have reported comparable efficacy and safety data (Takahashi, et al.
Gastric Cancer
2021). There are few evidence regarding the association between tumor response and survival time in later-line treatment with nivolumab alone for advanced GC. We therefore report results from post-hoc exploratory analyses of survival time by tumor response from the DELIVER trial.
Methods:
The DELIVER trial enrolled 501 patients (pts) with advanced gastric or GEJ adenocarcinoma treated with nivolumab alone. Primary endpoint was overall survival (OS), secondary endpoints were response rate (RR), disease control rate, progression-free survival (PFS), tumor regression rate / tumor progression rate at 1st evaluation, tumor growth rate, and safety. The exploratory analyses were performed for survival according to tumor response and depth of response (DpR) in pts with measurable lesions who were receiving nivolumab as 3rd or later-line treatment. The survival data was fixed at the timepoint of 2 years after the last enrollment.
Results:
234 pts were evaluable (median age 70y [26-90], 79% male, ECOG PS0/1/2 46/43/11%, 32% pts with ascites). Median OS was 6.5 months (95%CI 5.3-8.2) and median PFS was 1.8 months (95%CI 1.6-2.0). The RR was 15.0% (95%CI 10.4-19.5) with 5 complete response (CR) and 30 partial response (PR). The median PFS and OS were not reached for pts with CR, 11.7 and 29.8 months for pts with PR, 3.8 and 11.4 months for pts with stable disease, and 1.5 and 4.2 months for pts with progressive disease, respectively. In addition, the median DpR was -14.1% and was associated with PFS and OS in the Spearman analysis (r=0.55 and r=0.44, respectively). When the DpR was divided into 5 groups according to tumor shrinkage, there was difference in PFS and OS.
Conclusions:
This exploratory analysis indicated the association between DpR and survival time in pts with advanced GC treated with nivolumab alone in later-line. Increasing DpR was associated with longer median PFS and OS. Clinical trial information: UMIN000030850.
Median PFS(months)
HR,
p
-value
median OS (months)
HR,
p
-value
DpR≤-20% (n=100)
1.5
1
4.3
1
-20%<DpR≤0% (n=60)
1.7
0.57, 0.0011
5.3
0.89, 0.50
0%<DpR<30% (n=35)
3.0
0.24, <0.0001
7.0
0.68, 0.052
30%≤DpR<50% (n=17)
9.8
0.043, <0.0001
30.9
0.17, <0.0001
DpR≥50% (n=22)
15.8
0.049, <0.0001
Not reached
0.14, <0.0001
Clinical status
Clinical
19 organizations
1 drug
1 target
Organization
St. Marianna University School of MedicineOrganization
Osaki Citizen HospitalOrganization
Sakai City Medical CenterOrganization
Teine Keijinkai HospitalOrganization
Ikeda City HospitalOrganization
Ishikawa Prefectural Central HospitalOrganization
Higashiosaka City Medical CenterOrganization
Niigata Cancer Center Hospital, Niigata, JapanOrganization
Gifu University HospitalOrganization
Hyogo Cancer CenterOrganization
Hiroshima City Asa HospitalOrganization
Kansai Rosai HospitalOrganization
Showa University Research Administration CenterOrganization
Showa University School of MedicineOrganization
Showa University Fujigaoka HospitalOrganization
Japan Clinical Cancer Research OrganizationDrug
nivolumabTarget
PD-1