Survival outcomes associated with liver-directed therapies in patients with metastatic uveal melanoma.

person Michael M Caplan Columbia University Irving Medical Center, New York, NY info_outline Michael M Caplan, Lanyi Nora Chen, Venkatesh Krishnasamy, David Sperling, Joshua Weintraub, David DeStephano, Samuel M Pan, Diana McDonnell, Brian P Marr, Richard D. Carvajal, Shaheer Khan

Authors person Michael M Caplan Columbia University Irving Medical Center, New York, NY info_outline Michael M Caplan, Lanyi Nora Chen, Venkatesh Krishnasamy, David Sperling, Joshua Weintraub, David DeStephano, Samuel M Pan, Diana McDonnell, Brian P Marr, Richard D. Carvajal, Shaheer Khan Organizations Columbia University Irving Medical Center, New York, NY, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, Northwell Health Cancer Institute, New Hyde Park, NY Abstract Disclosures Research Funding No funding received None. Background: Metastatic uveal melanoma (mUM) is characterized by a hepatotropic pattern of spread and poor outcomes. Tebentafusp, the only FDA approved therapy, is restricted to patients (pts) with the HLA-A*02:01 genotype. As a result, a variety of liver-directed therapies (LDT) are commonly used for management of hepatic metastases. Methods: Pts with mUM with hepatic metastases who underwent LDT, including radiofrequency ablation, microwave ablation, hepatic metastatectomy, Yttrium-90 radioembolization (SIRT), transarterial chemoembolization (TACE), bland embolization, and immunoembolization (IE), were identified from an institutional database. Data collected included: age, gender, tumor location and size, baseline liver function tests (LFT) and lactate dehydrogenase (LDH), molecular tumor characteristics (where available), type(s) of LDT received, systemic therapies received, and vital status. Time from onset of hepatic metastasis until death (Liver-OS), as well as time from initial diagnosis of primary uveal melanoma until death (Ocular-OS) were calculated. Results: A total of 119 pts were identified. The median age at diagnosis was 53.8 years (range 26-83), 47% were female. At the time of LDT initiation, 33% had bilobar disease and 16% had extrahepatic metastasis. 18% pts had elevated LFTs and 55% had elevated LDH. 72% of pts had M1a disease, 24% had M1b and 4% had M1c disease. 45% of pts received more than one form of LDT. SIRT (31%) was the commonly administered initial LDT, followed closely by IE (26%) and TACE (9%). 86% of pts received systemic therapy including 42% who received immune checkpoint blockade overlapping with LDT. Molecular profiling in 26 pts revealed recurrent mutations in BAP1 (n = 18) and SF3B1 (n = 8). The median ocular-OS across all pts was 71.0 months (95% confidence intervals (CI), 62.8-99.4). The median liver-OS across all pts was 31.8 months (95% CI 25.2-35.3). In pts who received TACE, IE, or SIRT exclusively (n = 44), the median Liver-OS was 15.2 months (95% CI 12.8-NA) for TACE (n = 8), 23.3 months (95% CI 15.8-NA) for SIRT (n = 28), and 28.2 months (95% CI 22.6-NA) for IE (n = 8). Conclusions: Our results provide additional support for the utilization of LDT in pts with mUM, as demonstrated by improved OS compared to historical survival data.