Abstract
Clinical analysis of immunotherapy rechallenge in advanced gastric cancer.
Author
person
Xinxin Zhang
Henan Cancer Hospital, China, Zhengzhou, China
info_outline
Xinxin Zhang, Xinfang Hou
Full text
Authors
person
Xinxin Zhang
Henan Cancer Hospital, China, Zhengzhou, China
info_outline
Xinxin Zhang, Xinfang Hou
Organizations
Henan Cancer Hospital, China, Zhengzhou, China, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
Abstract Disclosures
Research Funding
Other Government Agency
Henan Province Medical Science and Technology Research Project (LHGJ20190627).
Background:
To evaluate the efficacy and influencing factors of programmed cell death protein 1 (PD-1) monoclonal antibody rechallenge therapy in advanced gastric cancer (GC).
Methods:
The clinical data of patients with advanced GC who were treated with PD-1 monoclonal antibody rechallenge in the Department of Gastroenterology, Henan Cancer Hospital from January 2020 to December 2021 were retrospectively collected.
Results:
A total of 60 patients with PD-1 monoclonal antibody rechallenge therapy were collected; the median follow-up time was 12.2 months. The median progression-free survival (PFS
2
) of PD-1 monoclonal antibody rechallenge therapy was 2.9 months, and the objective response rate (ORR) was 16.7%, and the disease control rate (DCR) was 55.0%. The median PFS
2
of the same PD-1 monoclonal antibody for the first and second versus different PD-1 monoclonal antibody rechallenge treatment was (3.5 months vs. 1.9 months,
P
=0.006). The median PFS
2
of positive PD-L1 expression in rechallenge therapy was 3.4 months, ORR was 22.7%, and DCR was 63.6%; the median PFS
2
was 4.5 months, ORR was 27.3%, and DCR was 54.5% in patients with median PFS
1
≥6 months. Multivariate analysis showed that peritoneal metastasis was independently associated with PD-1 monoclonal antibody rechallenge with median PFS
2
(
P
=0.034, HR=2.327, 95%CI 1.066-5.082). The incidence of adverse reactions in grade 1-2 and grade 3-4 of PD-1 monoclonal antibody rechallenge therapy was 83.3%, and 35.0%, respectively. and the safety was controllable.
Conclusions:
Rechallenge therapy with PD-1 monoclonal antibody is a feasible treatment in advanced GC, but the screening of suitable population for rechallenge therapy still needs prospective data analysis and verification.
4 organizations
1 drug
1 target
Organization
Henan Cancer HospitalOrganization
China National Biotec GroupOrganization
Zhengzhou GensciencesTarget
PD-1