Uterine sarcoma patients who underwent morcellation: Who are they? Results of the prospective intergroup real-world registry for gynecological sarcoma in Germany (REGSA- NOGGO RU1).

person Eva Roser Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie; Charité - Universitätsmedizin Berlin; Campus Virchow-Klinikum and North-Eastern German Society of Gynaecological Oncology (NOGGO), Germany, Berlin, Germany info_outline Eva Roser, Rebecca Mirbach, Peter Reichardt, Dario Zocholl, Maximillian Klar, Philipp Harter, Stefan Kommoss, Uwe Andreas Ulrich, Alexander Mustea, Pauline Wimberger, Michael Weigel, Matthias Frank, Barbara Schmalfeldt, Lars Ch. Hanker, Anne Flörcken, Tjadina Arndt, Klaus Pietzner, Jalid Sehouli

Authors person Eva Roser Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie; Charité - Universitätsmedizin Berlin; Campus Virchow-Klinikum and North-Eastern German Society of Gynaecological Oncology (NOGGO), Germany, Berlin, Germany info_outline Eva Roser, Rebecca Mirbach, Peter Reichardt, Dario Zocholl, Maximillian Klar, Philipp Harter, Stefan Kommoss, Uwe Andreas Ulrich, Alexander Mustea, Pauline Wimberger, Michael Weigel, Matthias Frank, Barbara Schmalfeldt, Lars Ch. Hanker, Anne Flörcken, Tjadina Arndt, Klaus Pietzner, Jalid Sehouli Organizations Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie; Charité - Universitätsmedizin Berlin; Campus Virchow-Klinikum and North-Eastern German Society of Gynaecological Oncology (NOGGO), Germany, Berlin, Germany, Charite-Universitätsmedizin Berlin, Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Berlin, Germany, HELIOS Klinikum Berlin-Buch, Klinik für Interdisziplinäre Onkologie, Sarkomzentrum Berlin-Brandenburg, Berlin, Germany, Institute for Biometry and Clinical Epidemiology, Charité-University Medicine of Berlin and North-Eastern German Society of Gynaecological Oncology (NOGGO), Berlin, Germany, University Hospital, Faculty of Medicine, Freiburg, Germany, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany, Department of Women's Health, Tuebingen University Hospital, Tuebingen, Germany, Department of Gynecology & Obstetrics, Martin-Luther Hospital Berlin, Berlin, Germany, Department of Gynecology and Gynecological Oncology, Bonn University Hospital, Bonn, Germany, North-Eastern German Society of Gynecological Oncology (NOGGO) and Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany, Frauenklinik, Leopoldina-Krankenhaus, Schweinfurt, Germany, ORTENAU KLINIKUM Offenburg-Kehl, Offenburg, Germany, Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Gynäkologie, Zentrum für Operative Medizin, Hamburg, Germany, University Hospital Schleswig-Holstein, Campus Luebeck, Lübeck, Germany, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Hematology, Oncology, and Tumor Immunology, Campus Virchow-Klinikum, Berlin, Berlin, Germany, North-Eastern German Society of Gynaecological Oncology (NOGGO) and Charite-Universitätsmedizin Berlin, Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Berlin, Germany, Charite-Universitätsmedizin Berlin, Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum and North-Eastern German Society of Gynaecological Oncology (NOGGO), Berlin, Germany Abstract Disclosures Research Funding Institutional Funding NOGGO, PharmaMar Background: Uterine sarcomas represent a group of rare malignant mesenchymal neoplasms with most types of them being associated with poor prognosis. In clinical practice, it is challenging to distinguish them from the most common benign tumors in women, so-called leiomyomas. Due to erroneous diagnosis, there is a risk of morcellating an occult sarcoma. This often leads to the distribution of malignant tissue in the abdominal cavity and a worse prognosis in most of the patients. In order to better understand this high-risk group of patients we analyzed their characteristics and management based on data of the real-world German registry for gynecological sarcoma (REGSA). Methods: REGSA is a real-world multicenter prospective registry including patients with gynecologic sarcomas in the primary and the recurrent situation of disease. For this work, we performed a descriptive analysis with data from all available patients with documented morcellation of uterine sarcoma. Results: 8.7% (n=76) of a total of 874 patients (registration period 09/2015-05/2022) were morcellated. Those 76 patients had a median age of 50.5 years. Thirty-seven patients (48.7%) were ≥50 years of age at the time of surgery. Leiomyosarcoma was the most common histopathological subtype (n=42; 50.3%). Fifty-eight patients (76.3%) had laparoscopic operations. A subtotal hysterectomy was the most common procedure used in 40.8% (n=31). Diagnostic curettage was performed in 5.3% of all cases (n=4). The predominant preoperative symptom was "bleeding disorders" in 19 patients (25.0%). Follow-up treatment after morcellation was heterogeneous. 17 patients received chemotherapy, with docetaxel and gemcitabine being the most frequently used regimen (n=8; 47.1%), followed by combinations with anthracyclines in 5 patients (29.4%). Conclusions: Many patients were over 50 years of age at the time of morcellation, although it is undisputed that the risk of morcellating occult uterine sarcoma increases with age. Whether curettage has diagnostic value needs to be further investigated. There is a high clinical need to define a consensus on further management of this high-risk group, regarding adjuvant therapy and follow-up care for there seems to be a great deal of uncertainty regarding adjuvant management.