Agranulocytosis secondary to cancer chemotherapy and association with higher in-hospital mortality in patients with central line insertion during hospital stay.

person Mohamed Zakee Mohamed Jiffry Danbury Hospital, Danbury, CT info_outline Mohamed Zakee Mohamed Jiffry, Felipe Carmona-Pires, Nkechi Okam, Jonathan Vargas, Mohammed Aimal Ahmed-Khan, Kayvon Moin, Meagan Josephs

Authors person Mohamed Zakee Mohamed Jiffry Danbury Hospital, Danbury, CT info_outline Mohamed Zakee Mohamed Jiffry, Felipe Carmona-Pires, Nkechi Okam, Jonathan Vargas, Mohammed Aimal Ahmed-Khan, Kayvon Moin, Meagan Josephs Organizations Danbury Hospital, Danbury, CT, American University of the Caribbean, Cupecoy, Sint Maarten (Dutch part) Abstract Disclosures Research Funding No funding received None. Background: Agranulocytosis secondary to cancer chemotherapy (ASCC) remains a leading cause of morbidity and mortality. Central line associated bloodstream infections (CLABSI) are also particularly prevalent in these populations and may portend a poorer outcome. Our study serves to investigate the relationship between patients with agranulocytosis secondary to cancer chemotherapy and insertion of a central venous catheter (CVC) with respect to in-hospital mortality. Methods: We utilized the National Inpatient Survey 2019 database. We utilized ICD-10 CM codes to identify ASCC and other medical comorbidities. We utilized ICD-10 PCS codes to identify CVC insertions. Multivariate logistic regression was utilized to study the effect of CVC insertion on in-hospital mortality. Results: In patients with ASCC, CVC insertion was associated with a higher in-hospital mortality (unadjusted: 11.9% vs 1%, p < 0.001, adjusted OR 19.27, 95% CI 5.84 – 65.6, p < 0.001) adjusted for baseline characteristics and other comorbidities. Patients in the study cohort who were older than 70 years of age also had a higher in-hospital mortality relative to younger age groups (adjusted OR 2.31, 95% CI 1.04-5.13, p < 0.039). Conclusions: In patients with ASCC, CVC insertion during the hospitalization is associated with a higher in-hospital mortality.