Stress as a predictor of tumor growth and development of metastases.

person Tristen Peyser University of Pittsburgh, Pittsburgh, PA info_outline Tristen Peyser, David A. Geller, Lauren Terhorst, Michael Antoni, Yoram Vodovotz, Leslie Hausmann, Donna Olejniczak, Aarshati Amin, Gauri J. Kiefer, Carol Lynn Hecht, Jessica Miceli, Albert Tong, Jonas T. Johnson, Marci Lee Nilsen, Dan Paul Zandberg, Vincent Edgar Reyes, Jennifer Steel

Authors person Tristen Peyser University of Pittsburgh, Pittsburgh, PA info_outline Tristen Peyser, David A. Geller, Lauren Terhorst, Michael Antoni, Yoram Vodovotz, Leslie Hausmann, Donna Olejniczak, Aarshati Amin, Gauri J. Kiefer, Carol Lynn Hecht, Jessica Miceli, Albert Tong, Jonas T. Johnson, Marci Lee Nilsen, Dan Paul Zandberg, Vincent Edgar Reyes, Jennifer Steel Organizations University of Pittsburgh, Pittsburgh, PA, University of Pittsburgh Medical Center Liver Cancer Center, Pittsburgh, PA, University of Miami, Coral Gables, FL, Univ of Pittsburgh Medcl Ctr Cancer Ctr, Uniontown, PA, University of Pittsburgh School of Medicine, Pittsburgh, PA, UPMC Hillman Cancer Center, Pittsburgh, PA, UPMC, Pittsburgh, PA Abstract Disclosures Research Funding Other National Cancer Institute Diversity Supplement, U.S. National Institutes of Health, R01CA196953 Background: The aims of this study were to examine; the predictors of perceived stress; and the associations between perceived stress and tumor growth and development of metastases as well as the mediational role of inflammatory biomarkers. Methods: This study is prospective in design. A battery of questionnaires, including a sociodemographic characteristic and the Perceived Stress Scale, was collected at baseline from patients diagnosed with solid tumors at various stages of treatment. Disease progression was measured over a 12-month period. Poverty threshold was determined using the U.S. Department of Health & Human Services 2020 poverty guidelines. Computerized tomography and Magnetic Resonance Imaging scans were assessed for disease progression between baseline and 12 months using Response Evaluation Criteria in Solid Tumors. Blood was collected and serum levels of IL-2, IL-1a, IL-1b, TNF-a, IL-6, and IL-8 were assessed. The predictors of stress include sociodemographic and disease specific characteristics. Primary outcomes were tumor growth and development of metastases. Descriptive statistics, correlations, and ordinal and linear regression were performed to assess the aims. Results: Of 159 patients diagnosed with cancer, 47.8% were male, mean age was 62.97 (SD = 10.35), 89.3% were Caucasian, and 13.8% met poverty guidelines. Significant predictors of stress were age (b=-.151, p=0.029, 95% C.I.=-2.86-.016) and income below the poverty threshold (b= 5.615, p=0.007, 95% C.I.=1.596-9.635). Gender was the only sociodemographic and disease specific factor significantly associated with disease progression. After adjusting for gender, greater perceived stress was associated with tumor growth and development of metastases (p =0.029), accounting for 33.3% of the variance. Circulating cytokines were significantly related to disease progression [IL-1a, p=0.020; IL-1b, p=0.011; IL-6, p<0.001; and IL-8, p<0.001] but not stress [IL-1a, p=0.369; IL-1b p=0.292; IL-2, p=0.470; IL6 p=0.406; and IL8, p=0.401]. Conclusions: Future research should evaluate inflammation in the tumor microenvironment as well as neutrophils and tumor suppressor genes as potential mediators between stress and disease progression.