Can hormone receptors prevent metastatic spread of gastric cancer?

person Irina V. Kaplieva Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation info_outline Irina V. Kaplieva, Oleg I. Kit, Elena M. Frantsiyants, Valeria A. Bandovkina, Yuriy A. Gevorkyan, Natalya V. Soldatkina, Nikolay S. Samoylenko, V. I. Aleynov, Irina S. Tishchenko, Maksim N. Duritskiy

Authors person Irina V. Kaplieva Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation info_outline Irina V. Kaplieva, Oleg I. Kit, Elena M. Frantsiyants, Valeria A. Bandovkina, Yuriy A. Gevorkyan, Natalya V. Soldatkina, Nikolay S. Samoylenko, V. I. Aleynov, Irina S. Tishchenko, Maksim N. Duritskiy Organizations Rostov Research Institute of Oncology, Rostov-on-Don, Russian Federation Abstract Disclosures Research Funding Other Background: The primary tumor and associated but distinct from it premetastatic niches include a number of important participants: immune cells, stromal cells, extracellular matrix and associated effectors, in particular hormone receptors. Cross-interaction between these components is key to tumor progression. The greater omentum and peritoneum are pre-metastatic niches for gastric cancer. The purpose of the study was to analyze levels of steroid hormone receptors in tissues of gastric cancer (GC) and its pre-metastatic niches: the peritoneum (P) and omentum (O). Methods: The main group included 21 patients with metastatic GC T 3-4 а N 0-3 M 1 ; the comparison group – 24 patients with non-metastatic GC T 3-4 а N 0-3 M 0 . Tissues of tumors, intact gastric tissues, omentum and peritoneum tissues were studied. The control group included 17 non-cancer patients; omental and peritoneal tissues were studied. Levels of receptors of estrogens (RE-α, RE-β), androgens (RA) and progesterone (RP4) were measured by ELISA. Results: Levels of RE-α in tissue of GC T 3-4 а N 0-3 M 1 were decreased by 1.7 times (P˂0.05) compared to controls, while in T 3-4 а N 0-3 M 0 they were increased by 1.2 times (P˂0.05). RE-β and RА did not change in both cases. RР4 in T 3-4 а N 0-3 M 1 was similar to control levels, and in T 3-4 а N 0-3 M 0 – was increased by 3.5 times. Levels of RE-α and β, RА and RР4 in O and P in T 3-4 а N 0-3 M 1 were similar to control levels, and in T 3-4 а N 0-3 M 0 they were higher: RE-α - by 3.9 and 2.4 times, RE-β– by 2.5 and 1.5 times (P˂0.05), RР4 – by 2.2 and 1.5 times (P˂0.05). RA in O and P in T 3-4 а N 0-3 M 0 was similar to control levels. Conclusions: Elevated levels of RE-α., RE-β and RR4 in peritoneal and omental tissues can be considered a factor associated with some characteristics of GC metastasis, and protective one at the same time. Obviously, levels of RE-α and RР in O and P correlate with the levels in tissues of GC T 3-4 а N 0-3 M 0 . However, this statement is disputable and requires further confirmation.