Accuracy of primary laparoscopic staging in patients with early ovarian malignancies: A retrospective multicenter study.

person Julia Caroline Radosa Department of Obstetrics and Gynecology, Homburg, Germany info_outline Julia Caroline Radosa, Pauline Mertke, Christoph Georg Radosa, Sara Brucker, Florin Andrei Taran, Stefan Kommoss, Uwe Ulrich, Andreas Hackethal, Martin Deeken, Marc P Radosa, Ingolf Juhasz-Böss, Erich-Franz Solomayer

Authors person Julia Caroline Radosa Department of Obstetrics and Gynecology, Homburg, Germany info_outline Julia Caroline Radosa, Pauline Mertke, Christoph Georg Radosa, Sara Brucker, Florin Andrei Taran, Stefan Kommoss, Uwe Ulrich, Andreas Hackethal, Martin Deeken, Marc P Radosa, Ingolf Juhasz-Böss, Erich-Franz Solomayer Organizations Department of Obstetrics and Gynecology, Homburg, Germany, Department of Obstetrics & Gynecology, Saarland University Hospital, Homburg, Germany, Institute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Dresden, Germany, Department of Women's Health, Tuebingen University Hospital, Tuebingen, Germany, Department of Gynecology & Obstetrics, Martin-Luther Hospital Berlin, Berlin, Germany, Tagesklinik Altonaer Straße, Frauenklinik an der Elbe, Hamburg, Germany, Knappschaftskrankenhaus Püttlingen, Püttlingen, Germany, Department of Gynecology & Obstetrivcs, Agaplesion Diakonie Hospital, Kassel, Germany, University of Saarland, Hombrug, Germany Abstract Disclosures Research Funding Other Foundation Background: Early ovarian malignancies (eOM) are often diagnosed incidentally in the course of diagnostic minimal invasive surgery or laparoscopy for preoperative suspected benign indications. To what extent initial minimal-invasive staging matches final FIGO stage following definite surgery is controversially discussed and current literature on this question is sparse. The aim of this study was to assess accuracy of laparoscopic staging of eOM with regard to final FIGO stage. Methods: We retrospectively identified all patients treated for eOM between 01/2000 and 10/2018. Participating sites were Gynecologic comprehensive cancer centers with great expertise in minimal invasive surgery. Inclusion criteria were no preoperative suspicion of advanced malignancy, initial staging laparoscopy, completion of surgical treatment via laparotomy and complete follow-up data. Clinical data and outcomes were abstracted from the medical record. Rate of upstaging and distinct causes were assessed and initial and definite FIGO stage and 3-year disease free (DFS) and overall survival (OS) were compared with regard to the incidence of upstaging. Results: 107 patients with eOM were included in the final analysis. In 72 (67 %) patients primary laparoscopic staging was concordant with final staging. 35 (33 %) cases were upstaged after the second operation. Regarding the cause for upstaging 4 (11 %) were upstaged because of infiltration of the contralateral ovarian capsule, 16 (46 %) because of peritoneal infiltrates and in 15 (43 %) patients an iatrogenic rupture of the ovarian tumor occurred during laparotomy. 21 (60 %) cases were upstaged within FIGO stage I and 14 (40 %) cases from stage I to II. Comparison of 3-year DFS and OS showed no differences regarding upstaging. Conclusions: In this population of patients with eOM, staging laparoscopy performed by specialized laparoscopic oncologic surgeons showed a sufficient accuracy with no case of upstaging to advanced FIGO stages. Regarding oncologic safety laparoscopic staging showed no impact on 3-year DFS and OS.