Assessment of breast cancer risk in BRCA carriers with ovarian cancer: Evaluation of data from longitudinal observation.

person Tamar Safra Tel Aviv Sorasky Medical Center, Tel Aviv, Israel info_outline Tamar Safra, Barliz Waissengrin, Deanna Gerber, Rinat Bernstein Molho, Amnon Amit, Lina Salman, Dana Josephy, Rakefet Chen-Shtoyerman, Ilan Bruchim, Melissa Kristen Frey, Bhavana Pothuri, Franco Muggia

Authors person Tamar Safra Tel Aviv Sorasky Medical Center, Tel Aviv, Israel info_outline Tamar Safra, Barliz Waissengrin, Deanna Gerber, Rinat Bernstein Molho, Amnon Amit, Lina Salman, Dana Josephy, Rakefet Chen-Shtoyerman, Ilan Bruchim, Melissa Kristen Frey, Bhavana Pothuri, Franco Muggia Organizations Tel Aviv Sorasky Medical Center, Tel Aviv, Israel, Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv, Israel, New York University School of Medicine, New York, NY, Chaim Sheba Medical Center, Ramat Gan, Israel, Rambam Health Care Campus, Haifa, Israel, Rabin Medical Center, Petah Tikva, Israel, Meir Medical Center, Kfar Saba, Israel, Kaplan Medical Center, Rehovot, Israel, Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Technion Israel Institute of Technology, Hadera, IA, Israel, Weill Cornell Medical College, New York, NY, New York University Cancer Institute, New York, NY Abstract Disclosures Research Funding Other Background: To confirm data from older studies reporting reduced risks of breast cancer (BC) in BRCA mutated (BRCA+) ovarian cancer (OC) patients and to re-evaluate BC surveillance and/or prophylactic mastectomy in OC patients. Methods: Data on 430 BRCA+ mutation carriers diagnosed with OC between 2000 and 2017 in 6 medical centers (one in the USA and five in Israel) were analyzed. Data included demographics, breast surveillance type, family history, BRCA mutation types, timing of BC diagnosis (before or after OC diagnosis) and family history of cancer. Results: Median age at diagnosis of OC was 55.4 years (range, 31.3-90) and median follow-up was 4.6 years. Most patients were BRCA1 (66.6%), and 35.7% had 185delAG. Most patients (68.4%) were Ashkenazi Jews, 27.4% had a family history of BC and 16.5% were diagnosed with BC before OC. Five percent developed BC following OC diagnosis with a median time to BC diagnosis of 68 months (range, 11-210). Of those diagnosed with BC, 50% had triple-negative BC, 40% had luminal B ER+, PR-, Her2-neg and 10% had luminal A -ER+, PR+, her2-neg. There was a non-significant increase in BC after OC, and in BC prior to OC diagnosis; there was no correlation of BC with family history. No definite deaths from BC were recorded. Conclusions: The incidence of BC after OC diagnosis in the BRCA+ population at a median follow-up of 4.6 years is consistent with prior series. Prophylactic bilateral Surveillance measures should be re-evaluated in this population and may only be needed in long-term disease-free survivors and/or subpopulations to be identified. Clinical trial information: 07-146.