24-HOUR PH MONITORING IN EVALUATION OF GASTRODUODENAL MOTILITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS

D.I. Abdulganieva, N. BelyanskayaKazan State Medical University, Kazan, Russian FederationObjectives: Evaluate changes in gastroduodenal motility according to 24-hour pH-metry in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods: 72 patients were prospectively enrolled into study, 33 patients with RA, mean age - 41,7±13,1, duration of the disease - 8,2±6,8 and 39 patients with OA, mean age 51,6±8,2, duration of the disease - 5,9±4,6 and 14 healthy controls. All included into the study were undergone upper gastrointestinal endoscopy, 24-hour pH-metry was done by ``Gastroscan-24'' (Fryazino, Russia) Epigastric pain was present in 27 (69,2%), heartburn – 26 (66,7%), regurgitation – 34 (87,2%), fullness after the meal – 15 (38,5%), nausea in 7 (17,9%) patients with RA. Epigastric pain was in 25 (75,8%) patients, heartburn – 27 (81,8%), regurgitation – 25 (75,8%), fullness after the meal – 6 (18,2%), nausea in 11 (33,93%) patients with OA. Results: 24 hour pH varied in different groups. In RA patients mean day pH was 2,41±0,27, mean night pH – 3,68±0,33 (p<0,05).In OA patients mean day pH was 2,85±0,26, mean night pH – 3,80±0,37 (p<0,05).In healthy controls mean parameters were increased at day time and decreased at day comparing to OA and RA groups - 3,11±0,22, and 2,41±0,27 (p<0,05) respectively. Analysis of pH-curves showed that bile gastroduodenal reflux at night was observed in vast majority of patients with RA and OA: in 23 (67,65%) patients with RA, in 20 (69%) patients with OA. In healthy controls - in 5 (35,71%) cases (p<0,05). Duration of bile reflux in 24 hour was 268,2±28,4 min in patients with RA, 255,7±27,2 min in patients with OA, 53,4±8,2 min in healthy controls (p<0,05). Patients with bile gastroduodenal reflux had correlation with epigastric pain and dyspeptic syndrome. Conclusions: Conclusion. Changes in 24 hour pH parameters in patients with RA and OA comparing to healthy controls may be explained by appearing of night bile gastroduodenal reflux, which may reflect impaired gastroduodenal motility in patients with RA and OA. Changes in upper gastrointestinal motility may have impact in epigastric pain and dyspeptic syndrome in these groups of patients. Disclosure of Interest: None DeclaredCitation: Annals of the Rheumatic Diseases, volume 70, supplement 3, year 2011, page 446Session: Rheumatoid arthritis – comorbidity and clinical aspects (Poster Presentations )