A NATIONWIDE POPULATION-BASED STUDY OF EPIDEMIOLOGY, RISK FACTORS FOR CYTOMEGALOVIRUS DISEASE IN AUTOIMMUNE INFLAMMATORY RHEUMATIC DISEASES

T. H. LI, Y. S. Chang, C. F. Su, C. C. Lai, C. C. Chuang, C. Y. TsaiShin Kong Wu Ho-Su Memorial Hospital, Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taipei, Taiwan, Republic of China National Yang Ming Chiao Tung University, Institute of Clinical Medicine, Taipei, Taiwan, Republic of China Fu Jen Catholic University, School of Medicine, New Taipei City, Taiwan, Republic of China Shin Kong Wu Ho-Su Memorial Hospital, Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, New Taipei City, Taiwan, Republic of China Shuang Ho Hospital, Taipei Medical University, Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, New Taipei City, Taiwan, Republic of China Taipei Veterans General Hospital, Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taipei, Taiwan, Republic of China  Background Human cytomegalovirus (CMV) ubiquitously distributes in general population but may cause overwhelming complications in patients with autoimmune inflammatory rheumatic diseases (AIIRDs); hence, the prevalence and associated factors of CMV disease in AIIRDs is worth investigating but the data has been limited. Objectives To investigate the epidemiologic data and risk factors of CMV infection in patients with AIIRDs. Methods The nationwide population-based cohort study was conducted by using Taiwanese National Health Insurance Database, to compare incidence rates (IR) with incidence rate ratios (IRR) of CMV disease in patients with AIIRDs and non-AIIRDs age- and sex-matched cohort; CMV disease was defined as pertinent ICD codes with concurrent anti-CMV medication administration. The individual data in various AIIRDs were analyzed and risk factors were identified by Cox proportional regression. Results 94,429 patients with AIIRDs and 1:1 number of matched subjects were identified; higher incidence rate of CMV disease in AIIRDs group was noted than the matched cohort. Various comorbidities and therapeutic agents including azathioprine, cyclosporin, cyclophosphamide, mycophenolate, intravenous steroid and oral daily dose > 7.5mg prednisolone or equivalence, were associated with CMV disease incidence. Comparing with RA, SLE and DM/PM posed increased risks on CMV disease. Conclusion Patients with AIIRDs carry higher risk of CMV disease regardless of etiologies, and attentiveness to one’s health is indispensable to facilitate early detection of CMV disease in patients with AIIRDs. References Zuhair M, Smit GSA, Wallis G et al. Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis. Rev Med Virol. 2019;29:e2034. Choo HMC, Cher WQ, Kwan YH et al. Risk factors for cytomegalovirus disease in systemic lupus erythematosus (SLE): a systematic review. Adv Rheumatol. 2019;59:12. Acknowledgements: NIL. Disclosure of Interests None Declared. Keywords: Inflammatory arthritides, Comorbidities, Epidemiology DOI: 10.1136/annrheumdis-2023-eular.1340Citation: , volume 82, supplement 1, year 2023, page 2055Session: Epidemiology, risk factors for disease or disease progression (Publication only)