An effect of dasd28 and ps-vas on haq-di score in rheumatoid arthritis patient

Background: Pain Score with visual analogue scale (PS-VAS) influences on Health Assessment Questionnaire Disease Index (HAQ-DI) in rheumatoid arthritis (RA) patient, as well as 28-joints disease activity score with C-reactive protein (DAS28-CRP). It is also suggested that these two indices have closely correlated and therefore have overlapping effect on HAQ-DI. However, the relationship of these indices for each other is still unclear. Objectives: Our aim is to clarify what affects most out of the overlap, and what would make influence on when dissociation between the two occurs. Methods: We have treated 549 RA patients consecutively more than four years. Their HAQ-DI, every component of DAS28-CRP, physician’s global assessment (EGA), PS-VAS, and Sharp/van der Heijde Score (SHS) were monitored every 3 months. From these patients studies concerning relationship between the parameters were investigated as follows; The relationship between average DAS28-CRP and average PS-VAS after the third year period was calculated using multivariate linear regression analysis (MLR). Then residuals of the each parameter from the approximate equation of MLR were calculated. From these residuals, correlation between residual of DAS28-CRP and disease duration (DD), HAQ-DI, age, SHS, physician’s global assessment (EGA), number of comorbidities in throughout treatment (Com) was evaluated with MLR. Correlation between residual of PS-VAS and DD, HAQ-DI, age, SHS, EGA, and Com was evaluated with MLR. Correlation between average HAQ-DI and the residuals, patient’s DD, age, SHS, EGA, and Com, was evaluated with MLR. In these analyses, statistical significance between parameters were evaluated statistically. Statistical significance was set lower than 1%. Results: Because of lacking of data, sixty-one cases had discarded, and then 488 cases had been analysed in this study. The approximate equation of the relation between DAS28-CRP and PS-VAS was “DAS28-CRP=1.543+0.1565 * PS-VAS” (R; 05050, Intercept; p=0, PS-VAS; p=0) and “PS-VAS=−0.6528+1.63 * DAS28-CRP” (R; 0.5050, Intercept; p=1.071*10–2, PS-VAS; p=0). Correlation coefficients of the approximate equation of the correlation between residuals of DAS28-CRP and the other parameters was 0.6398. Parameters that demonstrated within 1% of statistical significance were EGA (p=0), SHS (p=2.962*10–6), and Com (p=1.971*10–5). Correlation coefficients of the approximate equation of the correlation between residuals of PS-VAS and the other parameters was 0.4856. Parameters that demonstrated within 1% of statistical significance were Com (p=9.38*10–1), HAQ-DI (p=5.738*10–9), and SHS (p=1.594*10–7). Correlation coefficients of the approximate equation of the correlation between HAQ-DI and residuals of DAS28-CRP and PS-VAS, and DD, age, SHS, EGA, and Com, was 0.5848. Parameters that demonstrated within 1% of statistical significance were residual of DAS28-CRP (p=1.256*10–6), residual of PS-VAS (p=3.711*10–1), SHS (p=7.73*10–4), and age (p=2.389*10–1). Conclusions: These results suggest that the influence of DAS28-CRP and PS-VAS on the HAQ-DI score works in commonly overlapped. However, residual (the independent part) of DAS28-CRP from PS-VAS on HAQ-DI is not statistically evident. Residual of PS-VAS affects on the HAQ-DI score. SHS and Com affect on both of residuals. The HAQ-DI score is influenced by both of common and independent part of DAS28-CRP and PS-VAS, and SHS and age. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2018-eular.2167 Citation: Ann Rheum Dis, volume 77, supplement Suppl, year 2018, page A1298Session: Rheumatoid arthritis – prognosis, predictors and outcome