ANALYSIS OF 347 PATIENTS WITH UVEITIS IN A LARGE IBEROAMERICAN COHORT OF SPONDYLOARTHRITIS – THE RESPONDIA GROUP

P.D. Sampaio-Barros, C. Torres, A. Berman, R. Burgos-Vargas, M. Gutierrez, A. Barcelos, J. Chavez, M. Moreno, D. Palleiro, R. Saenz, I. Stekman, V. Azevedo, J.-A. Braga-da-Silva, G. Citera, D. Flores, C.R. Gonçalves, C. Graf, A. Nitsche, J. Saavedra, A.C. Ximenes, J. Vazquez-Mellado, E. Collantes-Estevez, RESPONDIA GroupRESPONDIA, São Paulo, Brazil RESPONDIA, Mexico City, Mexico RESPONDIA, Tucuman, Argentina RESPONDIA, Santiago, Chile RESPONDIA, Lisboa, Portugal RESPONDIA, Lima, Peru RESPONDIA, Quito, Ecuador RESPONDIA, Montevideo, Uruguay RESPONDIA, San José, Costa Rica RESPONDIA, Caracas, Venezuela, Bolivarian Republic Of RESPONDIA, Curitiba RESPONDIA, Brasilia, Brazil RESPONDIA, Buenos Aires, Argentina RESPONDIA, Goiania, Brazil RESPONDIA, Cordoba, SpainObjectives: The clinical and epidemiological characteristics of uveitis in the setting of spondyloarthritis (SpA) are well characterized in homogeneous populations. This study analyzed the presence of uveitis and its correlations in a large and heterogeneous cohort of SpA patients in Iberoamerica. Methods: A common protocol of investigation was applied to 2012 SpA patients in 85 centers in 9 Iberoamerican countries. Clinical and demographic variables, associated to disease indexes (BASDAI, BASFI, BASRI, MASES, ASQoL, SF-12), were investigated. Ankylosing spondylitis (AS) was the most frequent disease in the group (diagnosed in 62.9% of the patients), followed by psoriatic arthritis in 19.9%, undifferentiated SpA in 9.5%, reactive arthritis in 3.5%, enteropathic arthritis in 1.1%, and juvenile SpA in 3.2%. Results: Uveitis was observed in 372 SpA patients (18.5%); 74.7% of the patients with uveitis presented AS, followed by undifferentiated USpA (8.6%), reactive arthritis (6.5%), psoriatic arthritis (5.1%), enteropathic arthritis (1.6%), and juvenile SpA (3.5%). There was statistical association with pure axial disease (p < 0.001), inflammatory low back pain (p < 0.001), radiographic sacroiliitis (p < 0.001), enthesopathies (p = 0.004), uretritis/acute diarrhea (p < 0.001), balanitis (p = 0.002), Schober's test (p < 0.001), lateral lumbar flexion (p < 0.001), occiput-to-wall distance (p < 0.001), hip involvement (p = 0.002), HLA-B27 (p = 0.003), higher BASRI total (p < 0.001), higher BASRI hip (p < 0.001), and higher CRP (p = 0.001). The presence of uveitis was negatively associated to the number of painful (p = 0.03) and swollen (p = 0.005) peripheral joints. Although the mean age was similar in patients with and without uveitis, age at disease onset (p < 0.001) and age at diagnosis (p = 0.002) were earlier in patients with uveitis. There was negative association with psoriatic arthritis (p < 0.001), as well as with specific variables as psoriasis (p < 0.001), nail involvement (p < 0.001), and dactilitis (p = 0.062; trend); even axial disease in psoriatic arthritis presented significant lower frequency of uveitis than patients with AS (p < 0.001). No association with gender, race, BASDAI, BASFI, SF-12, and ASQoL were observed. Conclusion: Uveitis was a frequent extra-articular manifestation in SpA patients, positively associated to axial and hip involvement, and HLA-B27, and negatively associated to peripheral involvement and psoriatic arthritis. Disclosure of Interest: None declaredCitation: Annals of the Rheumatic Diseases, volume 69, supplement 3, year 2010, page 106Session: Abstract Session: Spondyloarthritis – clinical aspects (Oral Presentations )