ANALYSIS OF LEFT VENTRICULAR FUNCTION WITH ECHOCARDIOGRAM IN PATIENTS WITH PSORIATIC ARTHRITIS AND NOT DIAGNOSED CARDIOVASCULAR DISEASE

Background: It is known that some rheumatologic disorders may affect the cardiovascular system. In the last years, psoriatic arthritis (PsA) has been pointed out as one of those. Objectives: The aim of this study was to analyze if there was any subclinical dysfunction sign in patients with PsA of whom no cardiovascular disease had been diagnosed. Methods: Forty three patients with PsA were studied. A comprehensive echocardiogram was performed. Variables recorded for each patient were: left ventricular (LV) dimensions, LV and right ventricular (RV) systolic function, valve morphology and function, LV diastolic function assessment, and longitudinal strain (LS) assessment with speckle tracking imaging. Information on age, sex, cardiovascular risk factors (hypertension, diabetes, dyslipemia, renal disease and smoking), and evolution time of PsA was also recorded. An electrocardiogram was also carried out for each patient. Results: There were 23 men and 20 women. The mean age was 52±12 years old. The PsA mean evolution time was 6.8±5.3 years. Most of patients had at least one cardiovascular risk factor. All patients were in synusal rhythm. The LV end-diastolic diameter and ejection fraction, left atrium, and RV function were within normal limits. Men had overall a thicker interventricular septum (12±1.7 mm) when compared to women (9.7±1.6mm). 86% patients had a normal mitral valve function, as so 91% with aortic valve. None of them had findings suggesting pulmonary hypertension, or pericardial effusion. The diastolic function assessment in the general population revealed normal average of septal and lateral A' and S waves peak velocities, and E/E' ratio. Men had lower septal E' and S waves values and higher septal A' wave velocity. Nearly 50% of patients had a low septal E' or lateral E' wave peak velocity. 13 patients (30%) had impaired both septal E' and lateral E' waves, who were older and mainly men. The strain analysis showed an average of global LS - 17.9%±3%, two-chambers general LS -17.2%±5%, three-chambers general LS -19%±5.2%, and four-chambers general LS -17.3%±3.5%; without any significant difference between sex. 26 patients (60.5%) had global LS above normal limits; these were younger and with less PsA evolution time. Longitudinal strain values tended to be less negative at the basal level. Conclusions: Half of the patients with PsA were found to have some feature of diastolic dysfunction and more than the half of them had a slightly impaired global longitudinal strain value. Further studies could be of value to determine whether these findings would have a specific impact on the follow-up in this kind of patients. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2017-eular.2990Citation: Annals of the Rheumatic Diseases, volume 76, supplement 2, year 2017, page 1496Session: HPR measuring health (development and measurement properties of PROs, tests, devices) (Poster Presentations )