ANALYSIS OF SURVIVAL AT INTERSTITIAL PNEUMOPATHIES UNIT AFTER 14 YEARS FOLLOW-UP

M.M.R. Rodriguez Moreno , A.A. Romero Ortiz , M.M.T. Miranda León , I.I. Rodriguez Moreno Service of Rheumatology, Service of pulmonology, Chair of biostatistics. university of granada, Virgen de las nieves University Hospital, Granada, SpainObjectives: The objective of this study is to analyze Survival at Interstitial Pneumopathies Unit after 14 years follow-up.Methods: – Population object of study: 80 patients.– Variables: Global Survival, Response to therapy, First disease diagnosed.– Diagnostics criteria: ATS-ERS classification of Interstitial Pneumopathies, ARA criteria of Rheumatologic diseases.– Statistical Method: The data obtained were treated statistically whit the SPSS statistical Package (version 13.0). For study of Survival, Kaplan-Meier method with the corresponding tests were applied.Results: We have classified IP in 4 categories: Of Known cause (1 dead); Of Unknown cause (7 dead); Granulomatous (all alive); Others: Hystiocitosis, Lymphangioleiomyomatosis (1 dead). Mean of survival in months ± SE: 108±18; IC 95% (74;143). It not exists difference of survival in 4 groups studied.We have subclassified Lung Fibrosis in 3 groups: Idiopathic (7 dead), Secondary to drugs (1 dead) and Secondary to Rheumatologic disease (all alive). It not exists difference of survival in 3 groups studied, we have observed more mortality in Idiopathics than in others, but this result is not significant.We have considered 2 groups of Interstitial Pneumopathies: Interstitial Pneumopathies without Rheumatologic disease associated (IP) (8 dead), and IP associated with Rheumatologic disease (1 dead). Although is not significant, the result is near the signification. (p=0.10).– Survival of Interstitial Pneumopathies in function to the response at therapy: In the group of answer the treatment or stability we not observe dead to any type of Lung Fibrosis (Idiopathic or Secondary); but in non response group we observe significant differences between survival at the two groups of Lung Fibrosis: Idiopathic and Secondary. (p=0.017).The proportion of response to therapy is higher in Secondary Lung Fibrosis than in Idiopatic. The proportion of non response to therapy is higher in Idiopatic Lung Fibrosis respecting Secondary. (p=0.0000) IC 99% (0.0000;0.0005).– Survival of Interstitial Pneumopathies in function of first disease diagnosed were Rheumatologic or not: 72.2% were first diagnosed of Rheumatologic disease and second Lung disease; at the rest happened the reverse. We have applied Wilcoxon and Mann-Whitney U tests to know if the differences between Global Survival at Interstitial Pneumopathies and Rheumatologic diseases were significants according to if the first disease diagnosed were Rheumatologic or not; and we observe that Global Survival are more higher if the first disease diagnosed were Rheumatologic. (p=0.013).Conclusion: 1. Survival in patients with Interstitial Pneumopathies is related with the response to therapy. The proportion of response to therapy is more higher in Secondary Lung Fibrosis than in Idiopatic. (p=0.0000) IC 99% (0.0000;0.0005).2. Survival of Interstitial Pneumopathies is conditioned by the first disease diagnosed were Rheumatologic or not; and we observe that Global Survival are more higher if the first disease diagnosed were Rheumatologic. (p=0.013).3. No differences in Survival between the 4 categories of Interstitial Pneumopathies according ATS-ERS classification criteria was observed.4. We consider that these results are relevant, and it's necessary to create mixed Unit included Pneumologist and Rheumatologist in order to the adequate management of Interstitial Pneumopathies associated with Rheumatologic diseases.Citation: Ann Rheum Dis, volume 66, supplement II, year 2007, page 251Session: Miscellaneous rheumatic diseases