ANTIPHOSPHOLIPID SYNDROME - ATHEROSCLEROSIS AND CLINICAL-IMUNOLOGICAL CORRELATIONS

Background: Antiphospholipid syndrome (APS) is an autoimmune, multisystem disease characterized by thrombocytopenia, venous and/or arterial thrombosis, pathological course of pregnancy in women (preeclampsia, eclampsia, miscarriage) and the presence of a heterogeneous group of antibodies - antiphospholipid antibodies. Recent studies show that in the pathogenesis of atherosclerotic process relevant inflammatory component of the immune response, as well as elements of autoimmunity (autoantibodies and autoantigens autoreactive lymphocytes). A number of autoimmune rheumatic diseases, including RA, SLE and API are characterized by accelerated atherosclerosis and therefore an increased risk of cardiovascular morbidity and mortality. Objectives: The aim of the study was to investigate the incidence of cardiovascular events and atherosclerosis in patients with primary and secondary antiphospholipid syndrome, spyamo healthy subjects and patients with systemic lupus erythematosus without antiphospholipid antibodies. Objectives of the study: To compare the damage to aa. Carotes in patients with APS compared to healthy subjects and patients with SLE without antifosfolipindi antibodies. To compare Are score in patients with APS compared to healthy individuals without antifosfolipindi antibodies. To compare atherosclerosis of aorta in patients with APS compared to healthy subjects and patients with SLE without antifosfolipindi antibodies. To compare cutaneous vascular lesions (Raynaud, Livedo reticularis, periungual vasculitis, son pulp gangrene, asphyxia, vasculitis lesions) on the limbs and body in patients with API spyamo healthy subjects and patients with SLE without antifosfolipindi antibodies. Methods: For the purpose of this study examined 127 patients, 18 men (14%) and 109 women (86%), positive antiphospholipid antibodies. Patients were selected from the Department of Rheumatology, University Hospital “St. Ivan Rilski” – Sofia. All the patients were tested for: ANA, aPL, standart laboratory tests. Instrumental methods: calcium score of a. coronaria sinister, a. anterior descendens sinister, a. circumflexa sinister, a. coronaria dexter, Aorta, Valva aorte. Ultrasonographic examination of aa. Carotes to measure the Intima-media thickness. Results: It is proved strong, statistically significant correlation between aCL antibodies and the presence of plaques in the left common carotid artery (p=0.041). Absent the dependence between the antibody titers and incidence of carotid plaques. In the group with APS, 33,3% (14) establishes a positive calcium score of coronary arerii, 11.9% (5) plozhitelnite for aorta. Aortic valve Absent deposits. In the control group positive calcium score is when one person (5.88%). Conclusions: We found that patients with antiphospholipid syndrome suffer from early developmentof atherosclerosis. In the process of atherogenesis involved inflammatory componentof immune response. Atherosclerosis can be viewed as an inflammatory autoimmune disease. It is proved strong, statistically significant correlation between aCL antibodies and the presence of plaques in the left common carotid artery (p=0.041). Absent the dependence between the antibody titers and incidence of carotid plaques. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2017-eular.6615Citation: Annals of the Rheumatic Diseases, volume 76, supplement 2, year 2017, page 1233Session: SLE, Sjögren's and APS - clinical aspects (other than treatment) (Abstracts Accepted for Publication )