Abstract
Antiphospholipid syndrome (aps) in children
Full text
ME Pombo, R Merino, D Pascual, MV Cuesta, A Aguado, J García-ConsuegraRheumatology Service
Pediatric Rheumatology Unit
Inmunology Service
Hematology Service
Internal Medicine Service, Hospital Universitario La Paz, Madrid, SpainBackground
Objectives
To evaluate clinical features and management options of persistent antiphospholipid antibodies (aPL) in children.
Methods
Retrospective chart review of patients, seen between 1987 and 2000.
Results
Six patients with ages at diagnosis ranging from 9 to 13 years are presented. One of them with primary APS and 3 with SLE and asymptomatic aPL. The clinical manifestations are shown in the
Table 1
. All of the patients included were positive for lupus anticoagulant and all of them except the case 4 had positive tests for aCL and Aβ
2GPI
.
Abstract AB0102 Table 1
Clinical manifestations and treatment
Thrombotic events
Prophylactic treatment
Outcome
Follow up (years)
Recurrences
Case 1
DVT+Pulmonary embolism
Warfarin
Resolved
7
No
Case 2
Transient ischaemic brain attack
Aspirin
Resolved
9
No
Case 3
DVT
Aspirin
Resolved
9
No
Case 4
-
Aspirin
Unchanged
9
-
Case 5
-
Aspirin
Unchanged
8
-
Case 6
-
Aspirin
Unchanged
8
-
Conclusion
In paediatric patients with aPL, the risk of thrombosis, their recurrences and the management of oral anticoagulation may be different from adults.
Citation: Ann Rheum Dis, volume 60, supplement 1, year 2001, page A95Session: Anti-phospholipid syndrome
5 organizations
Organization
Inmunology ServiceOrganization
Hematology Service, DLM, NIH, Bethesda, MD