ASSESSMENT OF PROINFLAMMATORY MARKERS AND PERIPHERIC ATHEROSCLEROSIS IN PATIENTS WITH DECREASED BONE MINERAL DENSITY: A PILOT STUDY

Background: Recent studies have demonstrated that cardiovascular diseases and atherosclerosis are associated with reduced bone mineral density and osteoporosis (1, 2).Objectives: To assess the relation between atherosclerosis, bone mineral density and proinflammatory markers.Methods: Adults with low bone mineral density according to DEXA scores of lumbar and femoral region were recruited into the study consecutively. Atherosclerosis was assessed by coloured doopler bilateraly from carotis and popliteal arters and graded as 0-4. Subjects with atherosclerosis were accepted as patient group and those who had no atherosclerosis were accepted as control group. Blood osteocalcin, bone alkaline phosphatase (BAP), parathormone (PTH), TNF alpha, nitric oxide (NO), homosistein, calcium, magnesium, phosphore, lipid levels and urinary deoxypridinoline and calcium levels were assessed. Mann Whitney U, student's t and Pearson's correlation coefficient tests used for statistical analysis. p<0.05 accepted as significant.Results: Thirty one patients (15 female) and 38 controls (21 female) were recruited. The mean age of patients and controls were 61.97 (SD:7.88) and 58.29 (SD:9.30)respectively. There was not statistical difference between ages and genders of groups. The significant relation were found between femoral arter doopler grades and blood uric acid (p<0.005), WBC (p<0.05), and urinary deoxypridinoline (p<0.05) and calcium/24h (p<0.05) levels of female patients and controls. These parameters had not any significant relation between male patient and controls. There were no significant relation between peripheric atherosclerosis grades and DEXA scores, blood osteocalcin, BAP, PTH, proinflammatory markers (TNF alpha, NO), homosistein, calcium, magnesium, phosphore levels.Conclusion: Although there was not significant relation between the atherosclerosis,bone mineral density and proinflammatory markers, urinary deoxypridinoline which is one of the bone turnover marker had significant relation with atherosclerosis in females.References: 1. Baldini V et al. Cardiovascular disease and osteoporosis. J Endocrinol Invest 2005; 28 (10 Suppl): 69-72.2. Burnett JR, Vasikaran SD. Cardiovascular disease and osteoporosis: is there link between lipids and bone? Ann Clin Biochem 2002; 39:203-10.Citation: Ann Rheum Dis, volume 66, supplement II, year 2007, page 522Session: Osteoporosis