AUTOIMMUNE HEMOLYTIC ANEMIA IN CHRONIC LIVER DISEASES

N. Trad, G. Mohamed, S. Bizid, S. Soua, B. Ben Slimen, K. Boughoula, H. Ben Abdallah, R. Bouali, M. N. AbdelliMilitary Hospital of Tunis, Gastroenterology, Tunis, Tunisia  Background Chronic liver diseases can be associated with autoimmune diseases. their association with autoimmune hemolytic anemia (AIHA) is poorly studied. Objectives Our objective was to study the prevalence and the characteristics of AIHA in chronic liver diseases. Methods We performed a retrospective analysis of data from consecutive patients followed in our department for chronic liver diseases recruited from January 2010 to December 2019. The diagnosis of AHAI was retained in front of regenerative anemia with a positive direct coombs test and stigmata of hemolysis (free hyperbilirubinemia, elevated lactate dehydrogenase, and low haptoglobin) in the absence of other overt causes of constitutional or acquired hemolysis. Results A total of 187 patients were included with an average age of 60.2 years [11-89] and a sex ratio of 1.79. Thirteen patients had an AIHA (7%). Anemia was normocytic in 77% of cases and macrocytic in 23% of cases. Five patients had a history of associated autoimmune pathologies (38.4%); autoimmune thyroiditis in two cases, one case of psoriasis, one case of Sjögren’s syndrome and one case of autoimmune thrombocytopenia The AIHA was more frequent in cases of viral chronic liver diseases B and C (46.1%). Three patients had non-viral chronic liver diseases (23%): primary biliary cholangitis, autoimmune hepatitis, and alcohol. Conclusion In our study, AIHA was present in seven percent of cases, which would underline the importance of evoking it in the face of any anemia in the case of chronic liver diseases. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests None Declared. Keywords: Comorbidities, Diagnostic tests DOI: 10.1136/annrheumdis-2023-eular.1543Citation: , volume 82, supplement 1, year 2023, page 2019Session: Diagnostics and imaging procedures (Publication only)