BEHÇET`S DISEASE AND COURSE OF PREGNANCY - RESULTS FROM THE NATIONWIDE PREGNANCY REGISTER REVNATUS

Background: Behçets disease (BD) is a complex and multisystemic disorder of unknown etiology. It is characterized by recurrent oral and genital ulcers and inflammatory eye involvement. It can also affect the cardiovascular, pulmonary and skeletal system. BD is commonly diagnosed in women in reproductive age. Pregnancy outcomes are reported in previous studies with discrepancies in the rate of pregnancy-related complications. Objectives: To describe the course of pregnancy in patients with BD. Methods: We prospectively collected data on pregnancy outcome in women with BD through the nationwide Norwegian registry on pregnancy and rheumatic diseases (RevNatus) from 2016-2020. All women were diagnosed with ICD-10 code M35.2. 13 pregnancies in 11 women were recorded. One women had two pregnancies including one twin birth. Results: Median age at conception was 30 years (range 25-32), with median disease duration 7 years (range 1-15). There were no serious organ manifestations. Tnf-alpha-inhibitors were used in 2 trimester in 3 pregnancies. All pregnancies resulted in live births with median gestational age at delivery of 38 weeks (range 36-41). No preeclampsia or HELLP were recorded. Table 1. Pregnancy outcome in 13 BD pregnancies Patient # Pregnancy # Medication at 2.nd trimester Oral or genital ulcers during pregnancy Disease activity during pregnancy CRP value at 2nd trimester Gestational age at delivery, week Mode of delivery Birth weight, gram A 1 Azathioprine Colchicine LMWH no persistent* 13 38 SVD 3475 B 2 Adalimumab Colchicine LDPrednisolon yes persistent * 4 40 SVD 3215 C 3 no yes persistent* 5 41 SVD 3355 D 4 Adalimumab LDPrednisolon yes persistent* 23 36 SVD 1940 E 5 Etanercept ASA no 2 41 SVD 3410 6a (twin) Etanercept ASA no 5 37 Elective Sectio 2400 6b (twin) 2410 F 7 LDPrednisolon yes flare** 15 38 SVD 3180 8 Adalimumab LDPrednisolon yes flare** 4 37 Acute Sectio 3049 G 9 no no remission*** 1 41 SVD 3150 H 10 LDPrednisolon yes persistent * 10 38 SVD 2480 I 11 ASA no persistent* 3 39 SVD 3410 J 12 no yes persistent* 1 37 SVD 3115 K 13 Ciklosporine no remission*** 3 37 SVD 3130 SVD = spontaneous vaginal delivery, ASA = acetylsalicylic acid, LDPrednisolon = Low dose Prednisolon <10 mg/day, *= persistent throughout pregnancy, **= flare once during pregnancy, ***= remission throughout pregnancy Conclusion: Pregnancies in women with BD in this cohort were uncomplicated. We did not reveal any serious events, and they all resulted in live births. However, BD is a very heterogeneous disease, and the women in our cohort did not have any serious organ manifestations. Larger cohorts representing the heterogeneity are needed to study the course and outcome of pregnancies in BD. Disclosure of Interests: None declared Citation: Ann Rheum Dis, volume 80, supplement 1, year 2021, page 951Session: Other orphan diseases (POSTERS only)