Association of physical activity with self-reported quality of life after primary chemotherapy for ovarian cancer.

person Larissa Alejandra Meyer The University of Texas MD Anderson Cancer Center, Houston, TX info_outline Larissa Alejandra Meyer, Amy K. Schneider, Haleh Aghajani, Maria del Sol Basabe, Leidy Huie Martinez, Gladys M Estrada, Maria Iniesta-Donate, Yue Liao, Charlotte C. Sun

Authors person Larissa Alejandra Meyer The University of Texas MD Anderson Cancer Center, Houston, TX info_outline Larissa Alejandra Meyer, Amy K. Schneider, Haleh Aghajani, Maria del Sol Basabe, Leidy Huie Martinez, Gladys M Estrada, Maria Iniesta-Donate, Yue Liao, Charlotte C. Sun Organizations The University of Texas MD Anderson Cancer Center, Houston, TX, University of Texas at Arlington, Arlington, TX Abstract Disclosures Research Funding AstraZeneca National Cancer Institute/U.S. National Institutes of Health Background: Patients (pts) with advanced stage ovarian cancer may proceed to maintenance therapy or routine surveillance following primary treatment. As part of a larger research study to assess real world experiences of pts, we explored whether physical activity was associated with self-reported quality of life (QOL). Methods: Pts were asked to wear a wrist health tracker and complete the FACT-Ovarian (FACT-O) survey at baseline and every 3 months for up to 24 months. Total FACT-O score, including well-being subscales for physical (PWB), social (SWB), emotional (EWB), functional (FWB), and ovarian cancer-specific QOL were calculated. Health tracker data corresponding to each FACT-O 7-day recall period were analyzed. Multilevel linear regression analysis examined the relationship between FACT-O and 7-day health tracker data. The potential moderating effect by age (<60 vs. ≥ 60 yrs) was examined. Results: Data were analyzed for 77 pts with 250 total observations. Median age was 59 yrs (range 31, 82); 69% were White (6/53 pts self-identified as Hispanic), 4% Black, 9% Asian, 17% Other (13/14 pts self-identified as Hispanic). Of the 77 pts, 73% were married/partnered; median BMI 25.5; the majority had some college education. Pts completed a mean of 3 FACT-O surveys beyond baseline. Younger pts had better PWB (p<.01) and FWB (p<.01) than older pts, while older pts had better SWB (p<.01). Compared to older pts, younger pts had more daily activity minutes (19.9 vs 10.2, p<.01) and higher step counts (7035 vs 4689.8, p<.01). Apart from SWB and FWB with activity minutes, activity minutes and step counts were positively associated with FACT-O overall and subscale scores (Table). Older pts had stronger positive associations between physical activity minutes and PWB (p<.001), step counts and PWB (p<.001); step counts and FWB (p=.004), while younger pts had stronger positive associations between step counts and ovarian cancer-specific QOL (p=.03). Positive associations between physical activity minutes and SWB (p<.001) and EWB (p=.03), and ovarian cancer-specific QOL with activity minutes (p<.001) were observed only in younger patients. Conclusions: We observed positive associations between health tracker physical activity data and pt-reported QOL. Stronger associations were observed in younger pts. Interventions aimed at increasing physical activity may have broader quality of life benefits for individuals with ovarian cancer. Associations Between FACT-O and physical activity. Physical Activity Minutes Steps Beta Estimate p-value Beta Estimate p-value Total FACT-O Score 0.045 <.001 0.001 <.001 Ovarian cancer subscale score 0.016 <.001 0.0002 <.001 Physical Well-being Subscore 0.016 .001 0.0004 <.001 Social Well-being Subscore 0.001 .79 -0.0001 .31 Emotional Well-being Subscore 0.009 .006 0.0002 <.001 Functional Well-being Subscore 0.002 .69 0.0003 <.001