Abstract
Combination targeted therapy of avapritinib and sunitinib for patients with refractory advanced gastrointestinal stromal tumors after failure of standard treatments: Early results from a multi-institutional pilot study.
Author
person
Xinhua Zhang
Center of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
info_outline
Xinhua Zhang, Yanzhe Xia, Ming Wang, Tao Chen, Wei Li, Jian Li, Ye Zhou, Haoran Qian, Shirong Cai, Ke-Jing Tang, Yulong He
Full text
Authors
person
Xinhua Zhang
Center of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
info_outline
Xinhua Zhang, Yanzhe Xia, Ming Wang, Tao Chen, Wei Li, Jian Li, Ye Zhou, Haoran Qian, Shirong Cai, Ke-Jing Tang, Yulong He
Organizations
Center of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Department of Gastrointestinal Hernia Surgery, Nanfang Hospital Ganzhou Hospital, Ganzhou, Jiangxi, China, First Affiliated Hospital of Jilin University, Jilin, China, Beijing Cancer Hospital, Beijing, China, Fudan University Shanghai Cancer Center, Shanghai, China, Sir Run Run Shaw Hospital, School of Medicine, Hangzhou, China
Abstract Disclosures
Research Funding
No funding sources reported
Background:
The objective of this study was to explore the efficacy and safety of the combination of avapritinib and sunitinib in refractory GISTs.
Methods:
This was a multi-institutional prospective cohort study in part of a real-world trial (NCT05461664) exploring avapritinib in GIST patients (pts) after failure of standard treatments. From Jan 2022 to Sep 2023, participants were administered avapritinib at 100–200mg QD combined with sunitinib at 25–37.5mg QD continuously in 28-day cycles until PD or discontinuation. Clinical outcomes including ORR, survival and safety were assessed.
Results:
Twenty pts, generally heavily pretreated (65% with ≥4 prior TKIs, and 70% had progressed on ripretinib) were enrolled across seven participating centers. Median sum of target lesions was 27.0cm (range, 6.6–80.8). Among them, nine pts had primary
KIT 11
mutation, 10 harbored
KIT 9
and one harbored
KIT 17
. Nine pts had
KIT
activation-loop (AL) mutations without
KIT
ATP-binding pocket (ABP) mutations (
KIT
AL
pos
ABP
neg
), 2 had
KIT
ABP mutations without
KIT
AL mutations (
KIT
AL
neg
ABP
pos
). ORR was 20% (4 PR), 15 pts (75%) had SD, one (5%) had PD with a CBR (PR+SD≥16w) of 75%, assessed via mRECIST v1.1. Tumor shrinkage was observed in 18 pts (90%), with a median best percent change in target lesions of -20.2% (range, -54.5% to 16.1%). With a median follow-up duration of 11.3 months (range, 2.3–20.9), 12 pts progressed, 3 were withdrawal, 7 were dead and 5 continued to receive combination therapy. Median PFS (mPFS) was 6.6 months (95% CI 5.8-7.4). Median OS was not reached. mPFS in pts with primary
KIT 11
was similar compared to those with
KIT 9
. Regarding secondary
KIT
mutations, mPFS was numerically longer in
KIT
AL
pos
ABP
neg
pts compare to without (6.9 months VS 2.3 months, p=0.251). mPFS was significantly shorter in pts with
KIT
AL
neg
ABP
pos
than without (1.1 months VS 6.9 months, p<0.001). Three pts carrying
KIT 16 L783V
exhibited significantly longer mPFS than others (18.2 months VS 6.4 months, p=0.041). The dose of avapritinib (100–150 mg/d) and sunitinib (25–37.5 mg/d) could be tolerated. Common adverse events (AEs) were anemia, leukopenia, diarrhea, fatigue, periorbital and face oedema, and memory impairment. Common grade ≥3 AEs included leukopenia (30.0%), neutropenia (25.0%), anemia (20.0%), diarrhea (20.0%), and gastrointestinal hemorrhage (15.0%).
Conclusions:
The combination of avapritinib and sunitinib provided meaningful clinical benefit with an acceptable safety profile in pts with refractory GISTs, except for those harbored
KIT
AL
neg
ABP
pos
mutations. Clinical trial information: NCT05461664.
Clinical status
Clinical
3 organizations
2 drugs
1 target
Drug
avapritinibDrug
sunitinibTarget
KIT