Real life comparison between doxorubicin and cyclophosphamide (AC) dose-dense (dd) and conventional dose AC in patients with triple negative breast cancer (TNBC) under neoadjuvant treatment.

person Flavia Cavalcanti Balint A.C. Camargo Cancer Center, São Paulo, Brazil info_outline Flavia Cavalcanti Balint, Monique Celeste Tavares, Isadora Martins de Sousa, Ana Carolina Marin Comini, Italo Barradas e Silva Borges, Matheus Coimbra Barroso, Livia Alexandre Martins, Débora Guilherme de Albuquerque e Rodrigues de Sousa

Authors person Flavia Cavalcanti Balint A.C. Camargo Cancer Center, São Paulo, Brazil info_outline Flavia Cavalcanti Balint, Monique Celeste Tavares, Isadora Martins de Sousa, Ana Carolina Marin Comini, Italo Barradas e Silva Borges, Matheus Coimbra Barroso, Livia Alexandre Martins, Débora Guilherme de Albuquerque e Rodrigues de Sousa Organizations A.C. Camargo Cancer Center, São Paulo, Brazil Abstract Disclosures Research Funding No funding sources reported Background: High-risk early triple-negative breast cancer (TNBC) is frequently associated with early recurrence and high mortality. Studies suggest a sustained clinical benefit in patients with TNBC who have a pathological complete response (PCR) after neoadjuvant chemotherapy (NACT). The dose-dense (dd) regimen demonstrated improved survival regardless of hormone receptor expression or HER2 status. The doxorubicin and cyclophosphamide (AC) regimen can be performed in (dd), therefore it must include granulocyte growth factors, which may increase costs and toxicities. The object of the study was to evaluate their clinical characteristics and treatment, patients with TNBC, stage I-III who received ACdd in neoadjuvant treatment versus patients who received AC dose conventional (dc). Methods: We performed a retrospective observational cohort study of patients with early TNBC, stage I-III who received neoadjuvant treatment with chemotherapy based on doxorubicin, cyclophosphamide, paclitaxel and carboplatin associated with pembrolizumab. Results: All 82 patients were women 57.3% received ACdd, 30.4% received AC dc. In group ACdd 59.5% had intercurrence related with chemotherapy, in which 17.8% were neutropenic fever and 21.4% had developed different types of infections (ex: diarrhea, pneumonia and others). In these 2 groups all of them had received antibiotic. About 50% of the patients had developed intercurrence because of treatment toxicity and just 3.5% had disease progression. The other group that we evaluated is composed by patients who ACdc, dose Regarding to these group 48% developed any intercurrence during the neoadjuvant treatment, in which 8.3% had neutropenic fever and 25% had different types of infections. All of them earned antibiotic. About clinical and pathological response, the group that earned ACdd 61.7% got complete clinical response and 8.5% had a disease progression during the treatment. In the other arm 68% got complete clinical response and 4% had a progression. Conclusions: AC dd was more prevalent in our series, despite the additional use of granulocyte growth factor, there were more complications in this group and it did not demonstrate better results than those who received conventional dose AC.