Abstract
A single institution review of immunotherapy use, adverse events, and outcomes in early-onset cancer.
Author
person
Michael Daunov
University Hospitals Cleveland Medical Center, Cleveland, OH
info_outline
Michael Daunov, Chaim Domb, Matthew M. Mirsky, Jennifer Elizabeth Murphy, Jamie Abraham Perez, Jennifer Cullen, Kate Daunov, Melissa Amy Lumish
Full text
Authors
person
Michael Daunov
University Hospitals Cleveland Medical Center, Cleveland, OH
info_outline
Michael Daunov, Chaim Domb, Matthew M. Mirsky, Jennifer Elizabeth Murphy, Jamie Abraham Perez, Jennifer Cullen, Kate Daunov, Melissa Amy Lumish
Organizations
University Hospitals Cleveland Medical Center, Cleveland, OH, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, OH, University Hospitals Center for Clinical Research, Cleveland, OH, Case Western Reserve University School of Medicine, Cleveland, OH, University Hospitals, Cleveland, OH, Department of Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH
Abstract Disclosures
Research Funding
No funding sources reported
Background:
A significant portion of cancer patients are treated with immune checkpoint inhibitors (ICI) and many experience immune related adverse events (irAE) which impact treatment and outcomes. A paucity of data exists related to use of ICIs in Early Onset Cancers (EOC), their irAE, and its correlation to outcomes.
Methods:
A single institution database of immunotherapy use from an NCI-designated cancer center (NCI-CC) was reviewed with patients treated from 2010-2019. Two cohorts were examined: EOC (age ≤50 at diagnosis), and age > 50. Clinically significant irAEs were defined as those requiring hospitalization (≥grade 3). Pearson's Chi-squared test and Fisher's exact test were used for analysis. Significance was defined as p < 0.05.
Results:
A total of 1067 patients were identified, 173 were EOC. Race and ethnicity were similar between groups, the EOC group had significantly higher proportion of females, private insurance, working, single, treated at main campus, and ECOG 0. Main cancer types in EOCs were skin cancers (38.2%), lung (16.2%), and heme malignancies (11.6%); those > 50 were lung (46.6%), skin cancer (21.6%), and GU malignancies (11.2%). Stages of cancer were not statistically different nor was type or doses of ICI. EOCs were more likely to get a greater number of ICIs. IrAE requiring hospitalization were similar between groups; 20 (11.6%) in EOC vs 95 (10.6%) in > 50. There was no difference in the incidence of specific irAEs. Further stratification of EOC cohort by age group 13-30, 31-40, and 41-50 demonstrated no difference in experience of an irAE. Ipilimumab had the highest incidence of irAE in EOC; 12 (75.0%) vs 52 (33.1%), as did receiving 2+ ICIs: 11 (68.8%). The number of doses of a specific ICI was not correlated to irAE in EOC. EOC patients without an irAE were more likely to have a disease response; either stable disease, partial response, or a complete response: 21 (70.0%) vs 1 (12.5%); there was no difference in mortality.
Conclusions:
In a single NCI-CC review of ICI use, EOC had no difference in ≥grade 3 irAEs or in specific irAEs relative to older adults. Within EOCs, those who experienced a significant irAE were more likely to have received Ipilimumab or 2+ ICIs and were less likely to obtain a response to treatment, although mortality was not different.
Presence or absence of inpatient adverse events in patients aged ≤50 years at diagnosis.
Characteristic
No Inpatient IRAE
N = 157
1
Inpatient IRAE
N = 16
1
p-value
2
Age category
> 0.999
13-30
27 (17.2%)
3 (18.8%)
31-40
36 (22.9%)
3 (18.8%)
41-50
94 (59.9%)
10 (62.5%)
Immunotherapy
Atezolizumab
4 (2.5%)
0 (0.0%)
> 0.999
Durvalumab
1 (0.6%)
0 (0.0%)
> 0.999
Ipilimumab
52 (33.1%)
12 (75.0%)
< 0.001
Nivolumab
68 (43.3%)
7 (43.8%)
0.973
Pembrolizumab
44 (28.0%)
1 (6.3%)
0.073
Number of ICIs
0.004
1
106 (67.5%)
5 (31.3%)
2+
51 (32.5%)
11 (68.8%)
Response Assessment
0.003
PD
9 (30.0%)
7 (87.5%)
SD, PR, CR
21 (70.0%)
1 (12.5%)
Mortality
88 (56.1%)
9 (56.3%)
0.988
6 organizations
5 drugs
4 targets
Drug
ipilimumabDrug
AtezolizumabDrug
durvalumabDrug
nivolumabDrug
pembrolizumabTarget
CTLA-4Target
PD-L1Target
PD-1Organization
University Hospitals Cleveland Medical CenterOrganization
University Hospitals Seidman Cancer CenterOrganization
University Hospitals Sussex NHS Foundation Trust