Does Mirabegron Increase the Body Heat Generated by the Nervous System

2981

Acute mirabegron administration has been shown to increase brown fat activity in humans. Long-term mirabegron administration upregulates brown fat, and appears to improve glucose regulation, and change skeletal muscle phenotype.

2023-04-27

2024-01-17

2024-04-30

Completed

Early phase I

19

Inclusion Criteria: * age 18-40 years, * regular participation in more than 150 minutes of moderate intensity exercise, every week, during the previous two years. Exclusion Criteria: * History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes) * contraindication for mirabegron ingestion, such as previously diagnosed liver and/or kidney dysfunction, * use of medication that may unfavorably interact with mirabegron, including thioridazine (Mellaril™ and Mellaril-S™), flecainide (Tambocor®), propafenone (Rythmol®), digoxin (Lanoxin®) and solifenacin succinate (VESIcare®) * pregnancy or breast feeding * habitual use of tobacco/nicotine products (2 or more uses within the previous month) * any type of bladder dysfunction, taking medication related to bladder issues, or a history of bladder issues. * Sulfite Allergy '

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2024-06-06