Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients

RA56/006

To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.

2012-12-01

2013-12-01

2013-12-01

Completed

300

Inclusion Criteria: * age \>/= 18 years old * ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks * presence of symptom or sign of peritonitis * presence of WBC \>100cell/mm3 with PMN \>50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria Exclusion Criteria: * presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative * peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010 * hospital-acquired peritonitis * presence of catheter-related infection * history of peritonitis within 4 weeks * currently taking antibiotic * allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 300, 'type': 'ACTUAL'}}

2024-02-21