Clinical trial
Donepezil Use Versus Non-drug Approach in Treatment of Newly Diagnosed Alzheimer's Disease : a Multicentric, Randomized, Open Study : the CHOLINE-2 Study
Name
APHP201183
Description
Donepezil, as well as the other symptomatic drugs of Alzheimer's disease, is not any more reimbursed by the French healthcare system, due to a controversy about its efficiency. French health authorities currently preconize a non-rug approach based on cognitive remediation or stimulation.
The aim of this study is to compare the efficiency of the 2 approaches (non-drug versus donepezil) on the symptoms of Alzheimer's disease after 6 months of treatment.
Trial arms
Trial start
2022-02-10
Estimated PCD
2026-08-01
Trial end
2026-08-01
Status
Recruiting
Phase
Early phase I
Treatment
Donepezil
Donepezil 5 mg per day during one month, then 10 mg per day during 5 months.
Arms:
Cognitive remediation + Donepezil
Other names:
Aricept
Size
240
Primary endpoint
Difference of change in the MMSE score
26 weeks
Eligibility criteria
Inclusion Criteria:
* Diagnosis of Alzheimer's disease according to the IWG-2 criteria.
* Age ≥ 50 years.
* Absence of legal protection measures (guardianship, curatorship).
* MMSE score ≥ 10 at inclusion.
* abnormal values for Aβ42 in the CSF or Aβ40 / Aβ42 ratio.
* abnormal values for phosphorylated Tau in CSF
* Presence of a family carer or a person at home who can ensure compliance with treatment if MMSE score \<20.
* French native speaker.
Exclusion Criteria:
* Other cause of dementia.
* Previous use of symptomatic treatment for Alzheimer's disease.
* Hypersensitivity to donepezil hydrochloride or to any of the excipients listed in the SPC.
* Cardiological contraindication after possible opinion of a cardiologist, at the initiative of the investigator, in particular bradycardia, sinus disease or other supra-ventricular conduction abnormalities such as sinoatrial or atrioventricular block.
* Taking concomitant medications known to prolong the interval QTc
* Patients at particular risk of ulcer, known ulcer disease or receiving concomitant treatment with non-steroidal anti-inflammatory drugs.
* Patient at risk of urinary retention.
* History of epileptic disease.
* History of neuroleptic malignant syndrome.
* History of asthma or obstructive bronchopulmonary disease.
* Severe hepatic impairment.
* Taking one of the following treatments:
* CYP3A4 inhibitors, such as ketonazole.
* 2D6 inhibitors, such as quinidine.
* CYP3A4 inhibitors, such as itraconazole and erythromycin.
* CYP2D6 inhibitors, such as fluoxetine.
* Enzyme inducers such as rifampicin, phenytoin, carbamazepine.
* Antiarrhythmic class IA agents
* Antiarrhythmic class III agents
* other Antipsychotics such as phenothiazine, sertindole, pimozide, ziprasidone.
* some antiobiotics such as clarithromycine, erythromycine, levofloxacine, moxifloxacine.
* Participation in another interventional study.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 240, 'type': 'ESTIMATED'}}
Updated at
2023-11-30
1 organization
1 product
2 indications
Organization
Assistance Publique - Hôpitaux de ParisProduct
DonepezilIndication
Alzheimer's diseaseIndication
Early Onset