Evaluation of the Effect of Buffered Anesthetic Solution (Lidocaine 2%) in the Effectiveness of Inferior Alveolar Nerve Block Injection During the Treatment of Mandibular Primary Molars

UDDS-Pedo-03-2023

In a prospective, randomized clinical trial, triple-blind, split-mouth study, 40 children aged between 7 to 10 with bilateral mandibular primary molars were diagnosed with pulpitis. The test agent was 2% lidocaine with 1:80.000 epinephrine buffered with sodium bicarbonate 8.4% at a ratio of 1/10, as opposed to the control agent, which was non- buffered 2% lidocaine with 1:80,000 epinephrine. The pain will be assessed during inferior alveolar nerve block injection (IANB) and the effectiveness of anesthesia using the subjective Wong-Baker visual analog scale, the objective sound, eye, and motor (SEM) scale, and the physiological pain scale (pulse rate) using a pulse oximeter. The investigator has confirmed the onset of anesthesia after lip tongue-numbing by probing the gingiva until there is no pain. Endo-ice has been used to assess the onset of pulp anesthesia.

2022-12-01

2023-03-01

2023-04-03

Completed

Early phase I

40

Inclusion Criteria: * Children who are healthy and free of any underlying conditions that might make local anesthesia impossible to administer. * Children that are not allergic to (lidocaine, adrenaline, or sodium bicarbonate). * Children aged 6-10 years old * Cooperative children on Frankel scale (positive or absolute positive). * children needing bilateral (right and left) endodontic treatment for the mandibular primary molars. * A positive outcome on the cold test for the target tooth. Exclusion Criteria: * Uncooperative children on Frankel's scale (passive or absolute positive). * The presence of a fistula. * The presence of an abscess associated with the target tooth. * The presence of a periapical lesion radially. * Negative response to the cold test. * Children suffering from systemic conditions. * Children who are allergic to (lidocaine, adrenaline, sodium bicarbonate).

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2023-09-29