Does Subanesthetic Dose of Ketamine Given at Induction of Anesthesia Improve Postoperative Mood In Women Undergoing Fractional Curettage? A Randomized Controlled Trial

106/2022

When given intravenously in doses below 1.2mg/kg, ketamine has been shown to work as an antidepressant. Ketamine is a common induction drug used during general anesthesia. It is known to reduce postoperative pain in this instance. Limited studies have evaluated the effect of a single subanesthetic dosage of ketamine administered as an adjunct to general anesthesia on acute mood states in patients undergoing minor surgery. The aim of this randomized controlled study was to examine if a single intravenous administration of 0.5 mg/kg ketamine given at the induction of propofol/fentanyl anesthesia has an effect on acute mood states before the discharge of women undergoing fractional curettage.

2022-04-01

2022-09-01

2022-09-01

Completed

Early phase I

140

Inclusion Criteria: * consecutive patients (\>18 years) undergoing fractional curettage Exclusion Criteria: * American Society of Anesthesiologists' physical status ≥ 3 * History of psychological disorders * Use of drugs affect central nervous system * Substance abuse * Chronic pain * Pregnancy * Seizure disorders * Cardiovascular, hepatic or renal disease

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2023-12-06