Clinical trial

Analgesic Efficacy of Erector Spinae Block , Quadratus Lumborum Block and Intrathecal Morphine for Post Operative Pain Relief After Cesarean Section, A Prospective Randomized Single-Blind Controlled Study

NCT06088420

Name

17101962

Description

comparing analgesic efficacy of different nerve blocks on post operative cesarean sections.

Trial arms

Trial start

2023-10-01

Estimated PCD

2025-02-01

Trial end

2025-03-01

Status

Recruiting

Treatment

intrathecal morphine for intrathecal morphine group . bupivacaine 0.25% for Quadratus Lumborum and Erector Spinae nerve block groups .

Intrathecal morphine Group: All members of this group will receive spinal anesthesia with 12 mg 0.5% (2.2ml) hyperbaric bupivicane with intrathecal morphine(100mcg). QLB Group: All members of this group will receive bilateral quadratus lumborum block after spinal anesthesia at end of operation. The QLB will be performed by using bupivacaine 0.25% .ESB Group: All members of this group will receive bilateral erector spinae block after spinal anesthesia at end of operation. The ESB will be performed by using bupivacaine 0.25% (15 ml in each side) .

Arms:

Erector Spinae nerve block group, Intrathcal Morphine Group, Quadratus Lumborum nerve block group

Size

120

Primary endpoint

Duration of analgesia until first analgesic request.

24 hours .

Eligibility criteria

Inclusion Criteria: * 18-40 years old * more or equal 37 weeks of gestation * ASA 1,2 * Elective cesarean delivery Exclusion Criteria: * Patient refusal * inability to cooperate with or understand the study * local infection. * bleeding disorder * known anaphylaxis to any drug used in the trial * ASA physical status more than 2 * emergency operations * chronic opioid use (opioid use in the past 3 months) * Neurologic deficit or disorder * contraindication to regional anesthesia.

Protocol

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 120, 'type': 'ESTIMATED'}}

Updated at

2023-10-18

1 organization

1 product

1 indication

Organization

Assiut University

Product

Intrathecal Morphine

Indication

Postoperative Pain