Clinical trial
Randomized, Non-inferiority Trial Comparing a Dual Maintenance Therapy Strategy With Dolutegravir + Lamivudine (DTG/3TC) or Atazanavir/Ritonavir + Lamivudine (ATV/r+3TC) Versus the Standard WHO First Line Triple Therapy Tenofovir + Lamivudine + Efavirenz (TDF+3TC+EFV) or Dolutegravir + Lamivudine + Tenofovir (DTG+3TC+TDF) in West and Central African HIV-1 Infected Patients
Name
ANRS 12372 MODERATO
Description
MODERATO is a phase III, open-label, randomized, multicenter, non-inferiority trial conducted in West and Central Africa (Cameroon, Côte d'Ivoire, Burkina Faso).
HIV-1 infected adults receiving first line ART with TDF+XTC+EFV or DTG+XTC+TDF virologically suppressed will be recruited and followed during 100 weeks.
The objective is to assess the non-inferiority of a strategy consisting of switching to a dual maintenance therapy (DTG+3TC or ATV/r+3TC), comparing to WHO standard first line regimen (TDF+3TC+EFV or DTG+3TC+TDF), in terms of virological success at 96 weeks
Trial arms
Trial start
2020-09-21
Estimated PCD
2025-02-05
Trial end
2025-02-05
Status
Active (not recruiting)
Phase
Early phase I
Treatment
dolutegravir
One daily tablet (50mg) during 96 weeks
Arms:
Arm 1 : Dual maintenance therapy DTG+3TC
atazanavir boosted with ritonavir
One daily tablet with atazanavir (300 mg) boosted with ritonavir (100 mg) during 96 weeks
Arms:
Arm 2 : Dual maintenance therapy ATV/r+3TC
tenofovir + lamivudine +efavirenz or dolutegravir + lamivudine + tenofovir
One daily tablet with tenofovir 245 mg + lamivudine (300 mg) + efavirenz (400 mg) during 96 weeks OR One daily tablet with dolutegravir 50 mg + lamivudine (300 mg) + tenofovir (300 mg) during 96 weeks
Arms:
Arm 3 : Reference triple therapy TDF+3TC+EFV or DTG+3TC+TDF
Lamivudine
One daily tablet (300mg) during 96 weeks
Arms:
Arm 1 : Dual maintenance therapy DTG+3TC, Arm 2 : Dual maintenance therapy ATV/r+3TC
Size
480
Primary endpoint
The treatment success, as defined by using the FDA snapshot algorithm
90 to 102 weeks
Eligibility criteria
Inclusion Criteria:
* HIV-1 infection
* Age of legal majority
* CD4 \> 200 cells/mm3 at pre-inclusion
* Start first-line ART with non-nucleotide reverse transcriptase inhibitors including TDF+XTC+EFV for at least two years without a past history of virological failure, OR
* Be on TDF+XTC+EFV for at least two years then DTG+XTC+TDF without a past history of virological failure, OR
* Be on DTG+XTC+TDF (1st line regimen) for at least two years without a past history of virological failure
* Absence of past history of virological failure (viral load above the threshold corresponding to the test used); two blips between 50 and 200 copies/ml are allowed.
* At least 2 consecutive HIV-1 RNA \< 50 copies/ml within past 2 years, including HIV-1 RNA at pre-inclusion
* Women with pregnancy potential are required to use an effective contraceptive method throughout the study follow up.
* Signed informed consent
Exclusion Criteria:
* HIV-2 infection or HIV-1+2 infection
* CD4 nadir \<100 cells/mm3
* Chronic Hepatitis B (HBs Ag positive in the pre-inclusion balance)
* Ongoing active Tuberculosis
* Ongoing severe opportunistic infection
* Ongoing chemotherapy or immunotherapy
* Grade \> 2 hemoglobin, neutrophil or platelet disorder
* ALT≥ 3 times the upper limit of normal value
* Creatinine clearance \< 50 ml/min (CKD-EPI)
* Allergy to a trial drugs or drug component
* Ongoing pregnancy or Refusal of contraception
* Patient at risk of non-compliance
* Ongoing treatment with a drug that should not be associated with one of the drugs used in the study (cf appendix E page 77)
* Any symptoms or biological findings suggestive of a systemic disorder (renal, hepatic, cardiovascular, pulmonary) or other medical conditions that may interfere with the interpretation of test results or jeopardize the health of patients
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 480, 'type': 'ACTUAL'}}
Updated at
2023-09-06
1 organization
1 product
1 indication
Organization
ANRS, Emerging Infectious DiseasesProduct
dolutegravirIndication
HIV-1 infection