Compassionate Use Pan-VEGF Blockade for the Treatment of ROP (Compassionate Use BLOCK-ROP) Trial

CCI-09-00044

The purpose of this study is to provide access to intravitreal injection of Avastin in high-risk infants who do not otherwise qualify for study NCT00702819, an investigational multi-site study examining Avastin use for retinopathy of prematurity.

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Inclusion Criteria: * Inborn babies at CHLA NICU * Outborn babies transferred to CHLA NICU * Zone 1 or 2 ROP * Adequate/appropriate laser ablation * Failed standard laser treatment (persistent Plus disease at a minimum of 1 week post-laser) * Post-menstrual age greater than 30 weeks Exclusion Criteria: * Zone 3 ROP * Inadequate initial laser treatment * Most recent laser treatment less than 1 week * Evidence of tractional retinal detachment (exudative retinal detachment may be included in study group) * Post-menstrual age less than 30 weeks * Health not allowing for full protocol participation (determined by neonatologist)

{'studyType': 'EXPANDED_ACCESS', 'expandedAccessTypes': {'individual': True}}

2023-11-24