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Clinical trial

Effect of Transfusion of Plasma During Orthotopic Liver Transplantation on Endothelial Glycocalyx Layer and Short-term Outcome in Patients With End-Stage Liver Disease

ID
Name
LX-2019-LT-1
Description
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
Trial arms
Trial start
2023-10-01
Estimated PCD
2024-12-31
Trial end
2024-12-31
Status
Recruiting
Treatment
fresh frozen plasma
perform plasma transfusion in different phases during perioperation
Arms:
anhapetic group
blood sample
get blood samples at several specific points in time during perioperation
Arms:
anhapetic group, control group
Size
30
Primary endpoint
endothelial glycocalyx layer shedding markers
24 hours
Eligibility criteria
Inclusion Criteria: * Child A/B cirrhosis * patients who undergo the first OLT * Informed and consented * complete follow-up * cooperate with treatment Exclusion Criteria: * re-transplant * combined liver and other organ transplantation * BMI≥30Kg/m2 * patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion * acute liver failure
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 30, 'type': 'ESTIMATED'}}
Updated at
2023-11-24

1 organization

1 product

2 indications

Organization
Beijing Chao Yang Hospital
Product
Fresh frozen plasma
Indication
End Stage Liver Disease
Indication
Liver Transplant