Correlation Between Acute Analgesia and Long-Term Function Following Ankle

2013-12-126-004-0001

In this 4-arm pragmatic randomized control trial, the investigators hope to decipher whether the use of non-opioid analgesics (naproxen, celecoxib, acetaminophen) in addition to standardized physiotherapy during the acute phase of grade I-II ankle injuries will result in functional differences compared to standardized physiotherapy alone

2015-06-01

2019-05-01

2021-12-01

Completed

Early phase I

168

Inclusion Criteria: * Acquired acute ankle injury (injured less than 48 hours ago); * Clinical diagnosis of a Grade I or II ankle sprain * Is eligible to receive comprehensive medical care from Garrison Petawawa Exclusion Criteria: * Diagnosis of ankle fracture or ligament rupture * Has planned release from the Canadian Armed Forces within one year; * Documented restrictions on military duties * Has known intolerance or documented adverse reaction to acetaminophen or naproxen or celecoxib * Documented history of liver or kidney problems * pregnant or breastfeeding

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'maskingDescription': 'Patients are aware of their allocation. The treating physiotherapists will not be aware of allocation and patients are asked to not discuss their medication (allocation) with physiotherapists', 'whoMasked': ['CARE_PROVIDER', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 168, 'type': 'ACTUAL'}}

2024-02-12