Clinical trial
Pentoxifylline, Atorvastatin, and Vitamin E (PAVE) as Treatment for Radiation-Induced Erectile Dysfunction
Name
2018-0785
Description
This phase II trial studies how well pentoxifylline, atorvastatin, and vitamin E (PAVE) work in treating patients with erectile dysfunction after radiation therapy for prostate cancer. Atorvastatin may reduce high cholesterol. Pentoxifylline and vitamin E may enhance blood flow. Giving PAVE may work better in treating prostate cancer patients with post-radiation therapy erectile dysfunction.
Trial arms
Trial start
2019-11-20
Estimated PCD
2022-11-02
Trial end
2022-11-02
Status
Completed
Phase
Early phase I
Treatment
Atorvastatin
Given PO
Arms:
Treatment (atorvastatin, vitamin E, pentoxifylline)
Pentoxifylline
Given PO
Arms:
Treatment (atorvastatin, vitamin E, pentoxifylline)
Other names:
Oxpentifylline, Pentoxyphylline, PTX, Trental
Vitamin E Compound
Given PO
Arms:
Treatment (atorvastatin, vitamin E, pentoxifylline)
Other names:
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol, E Vitamin, Vitamin E
Size
14
Primary endpoint
Change in International Index of Erectile Function (IIEF) Scores
12 months
Eligibility criteria
Inclusion Criteria:
* Histologically or cytologically confirmed diagnosis of adenocarcinoma of the prostate
* Previous radiation therapy (any form) with curative intent for prostate cancer
* Erectile dysfunction, as determined by an International Index of Erectile Function (IIEF)-5 score of \< 22
* Normal testosterone (including men on testosterone replacement), defined as testosterone \> 150 ng/dl at the time of screening
* Karnofsky Performance Status (KPS) \>= 70, or Eastern Cooperative Oncology Group (ECOG) 0-2
* Patients may be taking an HMG-coA-reductase inhibitor
* Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\< 3 X upper limits of normal (ULN)
* Creatinine kinase \< 5 times ULN
* Normal renal function is defined as creatinine clearance \>= 30 ml/min via the Cockcroft Gault formula
Exclusion Criteria:
* No androgen deprivation therapy within the past 12 months
* No contraindication to an HMG-coA-reductase inhibitor, vitamin E or pentoxifylline
* Not currently taking cyclosporine, the human immunodeficiency virus (HIV) protease inhibitors, hepatitis C protease inhibitors, gemfibrozil, other fibrates, clarithromycin, itraconazole or strong inhibitors of CYP3A4
* No recent cerebral or retinal hemorrhage that in the opinion of the treating physician would make PAVE unsafe (within 6 months)
* No current chemotherapy during study participation
* No active liver or muscle disease that in the opinion of the treating physician would make PAVE unsafe
* No prior radical prostatectomy, cystoprostatectomy, abdominoperineal resection or retroperitoneal lymph node dissection
* Not currently taking a 5PDE inhibitor nor have used one within 30 days of enrolling in the study
* No recent deep venous thrombosis, myocardial infarction or pulmonary embolism (within 6 months) requiring continued anticoagulation other than aspirin (acetylsalicylic acid \[ASA\])
* No cardiac arrhythmias or artificial heart valves requiring anticoagulation other than ASA
* No concurrent drugs with anti-platelet therapy properties (e.g., P2Y12 inhibitors, non-steroidal anti-inflammatory agents, selective serotonin reuptake inhibitors) other than low dose ASA (81 mg/d)
* Not currently taking high dose statin therapy, defined as rosuvastatin \> 10 mg/d or atorvastatin \> 40 mg/d
* Not currently taking theophylline
* No history of active peptic ulcer disease in the past 6 months
* No history of intolerance to pentoxifylline or methylxanthines such as caffeine, theophylline and theobromine that in the opinion of the treating physician would make PAVE unsafe
* No concurrent use of CYP1A2 inhibitors (e.g., ciprofloxacin), ketorolac, or vitamin K antagonists (e.g. warfarin)
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 14, 'type': 'ACTUAL'}}
Updated at
2023-10-17
1 organization
1 product
1 drug
4 indications
Organization
M.D. Anderson Cancer CenterDrug
AtorvastatinIndication
Erectile DysfunctionIndication
Prostate CancerIndication
ImpotenceIndication
CTCAEProduct
Pentoxifylline