Clinical trial
A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Injection for Sedation in ICU Patients
Name
WHUICU202208
Description
A randomized non-inferior trial comparing remimazolam besylate with propofol for short-term sedation during invasive mechanical ventilation in intensive care units
Trial arms
Trial start
2023-02-28
Estimated PCD
2023-11-25
Trial end
2023-11-25
Status
Completed
Phase
Early phase I
Treatment
Remimazolam besylate
0\~2.0mg/kg/h
Arms:
Remimazolam besylate
Propofol
0.3\~4.0mg/kg/h
Arms:
Propofol
Remifentanil
1.5\~12μg/kg/h
Arms:
Propofol, Remimazolam besylate
Size
164
Primary endpoint
Successful sedation
24 hours
Eligibility criteria
Inclusion Criteria:
* Age ≥ 18 and ≤ 80 years
* Body mass index (BMI) ≥18 and ≤ 30 kg/m2
* Being Intubated and mechanically ventilated ≤48 hours before enrollment and expected to be on ventilator for at least 6 hours
* Requirement for light to moderate sedation (a Richmond agitation-sedation scale score of -2 to 1)
Exclusion Criteria:
* Refusal to be included
* Allergy or unsuitability to any composition of study drugs or remifentanil
* Living expectancy less than 48 hours
* Myasthenia gravis
* Status asthmaticus
* Abdominal compartment syndrome
* Serious hepatic dysfunction (CTP 10-15);
* Chronic kidney disease with glomerular filtration rate (GFR) \< 29 ml/min/1.73m2
* Mean blood pressure less than 65 mm Hg or the need of a continuous infusion of norepinephrine at ≥0.5 ug/kg/min to maintain Mean blood pressure ≥ 65 mm Hg
* Possible requirement for surgery or bedside tracheostomy in 24 hours
* Possible requirement for renal replacement therapy in 24 hours
* Acute severe neurological disorder and any other condition interfering with sedation assessment
* Abuse of controlled substances or alcohol
* Pregnancy or lactation
* Inclusion in another interventional trial in the past 30 days
* Other conditions deemed unsuitable to be included
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 164, 'type': 'ACTUAL'}}
Updated at
2024-01-31
1 organization
3 products
2 indications
Organization
Wuhan Union HospitalProduct
RemimazolamIndication
SedativeIndication
Mechanical VentilationProduct
PropofolProduct
Remifentanil