Evaluation of the Congruity of Methods Used in the Diagnostics of Chronic Endometritis in the Course of Infertility and the Effectiveness of Antibiotic Therapy in the Context of Remission of Symptoms and Obstetric Results

1072.6120.322.2020

Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma. Recent analyzes suggest that CE adversely affects fertility by reducing endometrial receptivity, impairing decidualization and uterine contractility, thus increasing the risk of recurrent pregnancy loss and implantation failure. It is likely that a significant proportion of idiopathic infertility cases are due to CE. The diagnosis of CE is a challenge because the clinical examination and transvaginal ultrasonography are considered non-specific. The recent scientific research has been aimed at identifying hysteroscopic CE diagnostic criteria and establishing the compatibility of ultrasonographic, hysteroscopic, histopathological (including the use of immunohistochemical testing with antibodies against human CD138) and microbiological diagnoses. Preliminary literature results suggested that successful treatment of CE with antibiotics could improve live birth rates.

2021-04-01

2022-10-30

2023-10-30

Completed

100

Inclusion Criteria: * age 18-45 years * lack of previous diagnosis and treatment due to suspected pathology of the uterine cavity * lack of active infection of the reproductive tract Exclusion Criteria: * pelvic surgery performed within 6 months preceding the hysteroscopy * confirmed pelvic endometriosis * antibiotic or probiotic treatment within 3 months preceding the hysteroscopy

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2023-11-18