Clinical trial
A Phase II Study of Sorafenib in Patients With Metastatic Renal Cell Carcinoma
Name
0081-06-FB
Description
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
PURPOSE: This phase II trial is studying the side effects and how well sorafenib works in treating patients with metastatic or unresectable kidney cancer.
Trial arms
Trial start
2007-03-01
Estimated PCD
2009-10-31
Trial end
2014-04-25
Status
Terminated
Phase
Early phase I
Treatment
Sorafenib
initial dose of Sorafenib will be administered orally with a dose of 400 mg twice a day, daily.Intrapatient dose escalation will occur providing no dose limiting toxicity (Grade 3 or 4) is observed. Dose level 2 600mg. Dose level 2 800mg
Arms:
Sorafenib
Other names:
Nexavar
Size
14
Primary endpoint
Toxicity of Intrapatient Dose Escalation of Sorafenib Tosylate
Study completion
Eligibility criteria
DISEASE CHARACTERISTICS:
Inclusion Criteria:
* Histologically or cytologically confirmed renal cell carcinoma (RCC)
* Must have a component of conventional clear cell RCC
* Predominant clear cell component ≥ 75%
* Metastatic or unresectable disease (Measurable disease is defined as any lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm by conventional techniques or ≥ 10 mm by spiral CT scan or MRI)
* Measurable or nonmeasurable disease, includes any of the following:
* Small lesions, longest diameter \< 20 mm by conventional techniques or \< 10 mm by spiral CT scan
* Bone lesions
* Leptomeningeal disease
* Ascites
* Pleural/pericardial effusion
* Lymphangitis cutis/pulmonitis
* Abdominal masses that are not confirmed and followed by imaging techniques
* Cystic lesions
* Irradiated lesions, unless progression is documented after radiotherapy
* Paraffin RCC tissue blocks or unstained slides must be obtained for future chemistry staining of VEGF
* Karnofsky performance status 70-100%
* Fertile patients must use effective contraception (hormonal and/or barrier method) during and for 3 months after completion of study treatment
* Granulocyte count ≥ 1,500/µL
* Platelet count ≥ 100,000/µL
* AST/ALT ≤ 2.5 times upper limit of normal (ULN)
* Alkaline phosphatase ≤ 2.5 times ULN
* Serum bilirubin ≤ 1.5 times ULN
* Protein ≤ 1+ by urinalysis
* Creatinine ≤ 1.5 times ULN
* At least 4 weeks since prior major surgery and/or radiotherapy and recovered
* Prior palliative radiotherapy for metastatic lesion(s) allowed provided there is at least one measurable and/or evaluable lesion(s) that has not been irradiated
* More than 4 weeks since prior and no other concurrent anticancer therapy
* Concurrent continuation of bisphosphonates allowed for bone metastases prophylaxis
Exclusion Criteria:
* Patients with true papillary, sarcomatoid features without any clear cell component, chromophobe, oncocytoma, collecting duct tumors, or transitional cell carcinoma are not eligible
* No evidence of CNS metastases
* No imaging (MRI or CT scan of the brain) abnormality indicative of CNS metastases within past 42 days
* Not pregnant or nursing (negative pregnancy test)
* No ongoing hemoptysis
* No cerebrovascular accident within the past 12 months
* No peripheral vascular disease with claudication while walking less than 1 block
* No history of clinically significant bleeding
* No deep venous thrombosis or pulmonary embolus within the past year
* No significant cardiovascular disease, defined as NYHA class II-IV congestive heart failure, angina pectoris requiring nitrate therapy, or myocardial infarction within the past 6 months
* No uncontrolled hypertension, defined as systolic BP \> 160 mm Hg and/or diastolic BP \> 90 mm Hg while on medication
* No preexisting thyroid abnormality whose thyroid function cannot be maintained in the normal range by medication
* No uncontrolled psychiatric disorder
* No delayed healing of wounds, ulcers, and/or bone fractures
* No currently active second malignancy except nonmelanoma skin cancer (patients are not considered to have a 'currently active' malignancy if they have completed anticancer therapy and are considered by their physician to be at less than 30% risk of relapse)
* No more than one prior systemic therapy for RCC
* No prior vascular endothelial growth factor receptor agents
* No concurrent systemic corticosteroid therapy (except replacement therapy for adrenal insufficiency)
o Topical and/or inhaled steroids allowed
* No concurrent full-dose oral or parenteral anticoagulation
o Low-dose warfarin (1 mg) for maintenance of catheter patency or daily prophylactic aspirin allowed
* No concurrent Hypericum perforatum (St. John's wort)
* No concurrent ketoconazole, itraconazole, ritonavir, rifampin, or products containing grapefruit juice
* No concurrent hormonal therapy or chemotherapy o Concurrent hormones administered for non-disease related conditions (e.g., insulin for diabetes) allowed
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 14, 'type': 'ACTUAL'}}
Updated at
2023-10-26
1 organization
1 product
1 indication
Organization
University of NebraskaProduct
SorafenibIndication
Renal Cell Carcinoma