Clinical trial
Randomized, Controlled Cross-over Comparison of Cannabinoid to Oral Opioid for Postoperative Photorefractive Keratectomy Pain Control
Name
IRB202201660 -A
Description
Photorefractive Keratectomy (PRK) is a commonly performed corneal refractive surgery but has significant post-operative pain. Pain medications after PRK are typically opioid-acetaminophen combinations. Alternatives to opioid medication are worth consideration. Patients will receive PRK in each eye sequentially, using the cannabinoid or codeine/acetaminophen for one eye and the other treatment for the fellow eye two weeks later.
Trial arms
Trial start
2024-02-01
Estimated PCD
2025-09-01
Trial end
2025-09-01
Status
Recruiting
Phase
Early phase I
Treatment
oral cannabinoid
dronabinol
Arms:
Oral cannabinoid
Other names:
dronabinol
oral codeine/acetaminophen
10 tablets of acetaminophen-codeine combination (300-30mg) without refills.
Arms:
Oral codeine/acetaminophen
Size
35
Primary endpoint
Pain as recorded by the FACES scale
1 week
Eligibility criteria
Inclusion Criteria:
* Adults older than 18 years with refractive stability for 1 year electing to have PRK surgery
* Consenting to participate
* Not meeting exclusion criteria will be included in the study population.
Exclusion Criteria:
* Patients not candidates for PRK will be excluded from the study.
* Patients taking other pain medications for concomitant medical conditions including, but not limited to tricyclic antidepressants, gabapentin and tramadol will be excluded from the study.
* Additional exclusion criteria will be known or suspected allergy or hypersensitivity to any of the routine or study medications.
* Patients completing follow up appointments at anywhere other than UF Health Ophthalmology clinic at the Oaks will not be enrolled in the study.
* Patients who are pregnant or nursing are not eligible for PRK, and such patients are not eligible to enroll in this study. Female patients of child-bearing age will be pregnancy tested before surgery and study enrollment.
* Patients will be specifically counseled, and it will be noted in the written informed consent that use of the cannabinoid product may result in a positive THC urinalysis screening test so they may self-exclude if such a situation could cause social and/or employment conflict.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 35, 'type': 'ESTIMATED'}}
Updated at
2024-02-21
1 organization
2 products
3 indications
Organization
University of FloridaProduct
Oral CannabinoidIndication
PRKIndication
MyopiaIndication
HyperopiaProduct
Oral Codeine + Acetaminophen