Clinical trial
Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial
Name
23-041
Description
The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.
Trial arms
Trial start
2024-01-01
Estimated PCD
2025-01-01
Trial end
2025-09-01
Status
Recruiting
Phase
Early phase I
Treatment
Calcium hydroxide
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Arms:
Conventional calcium hydroxide in paste form
nano calcium hydroxide
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Arms:
Nano calcium hydroxide in hydrogel form, Nano calcium hydroxide in paste form
Size
54
Primary endpoint
bacterial count
on the seventh day from intercanal medication placement appointment
Eligibility criteria
Inclusion Criteria:
* healthy males and females.
* age range between 21-49.
* patients with no physical disability or psychological problems.
* patients presenting with single permanent molar with signs and/or symptoms of apical periodontitis, and having Periapican index ≥ 2.
Exclusion Criteria:
* pregnant women.
* patients with immune-compromised disease.
* patients with complicated systemic diseases.
* patients who took antibiotics within a period of 1 month.
* patients with known sensitivity to the medicaments or pharmaceuticals used in this study.
* Non-restorable teeth including root fractures, and/or advanced periodontal involvement.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2', 'PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 54, 'type': 'ESTIMATED'}}
Updated at
2024-01-09
1 organization
2 products
3 indications
Organization
British University in EgyptProduct
Calcium hydroxideIndication
Endodontic DiseaseIndication
Pulp DiseaseIndication
ToothacheProduct
Nano Calcium Hydroxide