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Clinical trial

Comparing the Analgesic Effects of Different Doses of Dexmedetomidine as an Adjuvant in External Oblique Intercostal Plane Block in Splenectomy: A Randomized Trial

ID
Name
36264PR604/3/24
Description
The aim of this study is to compare the analgesic effects of different doses of dexmedetomidine as an adjuvant in external oblique intercostal plane block (EOIPB) in splenectomy.
Trial arms
Trial start
2024-04-20
Estimated PCD
2024-10-01
Trial end
2024-10-01
Status
Not yet recruiting
Treatment
Dexmedetomidine 0.5 μg/kg
Patients will receive 29 ml bupivacaine 0.25% + 1 ml dexmedetomidine 0.5 μg/kg diluted in saline.
Arms:
Group dexmedetomidine 0.5
Dexmedetomidine 1 μg/kg
Patients will receive 29 ml bupivacaine 0.25% + 1 ml dexmedetomidine 1 μg/kg diluted in saline.
Arms:
Group dexmedetomidine1
Size
50
Primary endpoint
Time to the 1st rescue analgesia
48 hour Postoperatively
Eligibility criteria
Inclusion Criteria: * Age ≥ 18 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status II-III. * Scheduled for splenectomy. Exclusion Criteria: * Body mass index (BMI) ≥35 kg/m2 * History of abdominal surgery. * Infection at the injection site. * Drug abuse. * Allergic reaction to local anesthetics. * Coagulation abnormalities. * Pregnancy. * Severe cardiovascular problems. * Diabetic neuropathy.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 50, 'type': 'ESTIMATED'}}
Updated at
2024-04-12

1 organization

1 product

3 indications

Organization
Tanta University
Product
Dexmedetomidine
Indication
Dexmedetomidine
Indication
Oblique Intercostal Plane Block
Indication
Splenectomy