Clinical trial
Phase III RCT of the Effectiveness of Silver Diamine Fluoride in Arresting Cavitated Caries Lesions
Name
HUM00147622
Description
This trial is a Phase III, multisite, randomized, placebo-controlled trial, with two parallel groups. The groups are SDF or placebo and they are applied every 6 months. The primary hypothesis of the trial is that SDF is better than placebo for stopping cavities with dentin exposed in baby teeth when assessed at 6 months after initial application.
Trial arms
Trial start
2018-10-08
Estimated PCD
2023-04-11
Trial end
2023-04-27
Status
Completed
Phase
Early phase I
Treatment
Silver Diamine Fluoride
SDF will be applied twice during the study
Arms:
Silver Diamine Fluoride (SDF)
Other names:
Diammine Silver Fluoride
Placebo
This is being compared to the SDF and will also be applied twice
Arms:
Placebo
Size
831
Primary endpoint
The proportion of arrested trial lesions per child in each treatment arm after one treatment with SDF or Placebo
6 months
Eligibility criteria
Inclusion Criteria:
* Child:
* Male or female, between 12-71 months of age at baseline, up to the day the child turns 6 years old.
* Must allow examination of the oral cavity and application of treatment by the examiners at baseline.
* Must have S-ECC \[defined as: In children younger than age 3, any sign (non-cavitated or cavitated lesion) of caries in any tooth surface (i.e., most common for this age group will be on erupted smooth surfaces). From ages 3 through 5, ≥1 dmfs in maxillary anterior teeth; or a dmfs score of ≥4 (age 3), ≥5 (age 4), or ≥6 (age 5) constitutes S-ECC. Note: The "d" component of the dmfs index is defined as including cavitated and non-cavitated lesions, thus ICDAS\>1\].
* Have at least one SDF-target tooth with
* Soft cavitated caries lesions extending into dentin \[ICDAS 5 or 6\];
* Cavitated lesion(s) that allow for direct hardness assessment and application of SDF (microbrush applicator must fit the cavity and be able to access all exposed dentin).
* Parent/Legal Guardian:
* Provide written informed consent for the child and her/himself prior to participation.
* Must be at least 18 years old, or an emancipated minor who provides documentation of emancipation.
* Must be willing and able to participate in trial activities.
Exclusion Criteria:
* Child:
* Hereditary generalized developmental dental defects such as Amelogenesis Imperfecta and Dentinogenesis Imperfecta.
* Known allergy/sensitivity to silver or other heavy metal ions.
* Presence of any gingival or peri-oral ulceration, abscess or stomatitis.
* Participating in the foster care system at trial initiation.
* Toothache pain at baseline (based on Dental Discomfort Questionnaire score of 1 or higher).
* Note: If toothache pain occurs after baseline, the child remains eligible to continue in the trial as long as he/she has at least one trial tooth that meets tooth inclusion/exclusion criteria.
* Demonstrated inability to comply with trial protocol requirements (determination is at the Clinical Site Investigator's discretion).
* Rickets.
* Osteopenia or osteoporosis (e.g., Osteogenesis Imperfecta, Ehlers-Danlos Syndrome, Marfan Syndrome, etc.).
* Chronic diseases such as chronic kidney disease, leukemia, lymphoma, rheumatic disorders, etc.
* Metabolic bone disease (e.g., Galactosemia, Glycogen Storage Disease Type 1, etc.).
* Chronic glucocorticoid, anticonvulsants, chemotherapy, bisphosphonate administration.
* Hypothyroidism, hyperparathyroidism, impaired glucose tolerance, hypocalcemia or hypophosphatemia.
* Tooth:
* Pain due to caries (based on DDQ score of 1 or higher).
* Note: If toothache pain occurs after baseline, the tooth is removed from the study.
* Pulpal exposure, or signs of pulpal infection (abscess, fistula, swelling).
* Mobility not associated with expected exfoliation patterns.
* Parent/Legal Guardian:
* Demonstrated inability to comply with trial protocol requirements (determination is at the Clinical Site Investigator's discretion).
* Inability to read and comprehend the consent document or trial questionnaires in the translated languages available.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 831, 'type': 'ACTUAL'}}
Updated at
2024-04-08
1 organization
1 product
1 drug
1 indication
Organization
University of MichiganProduct
Silver Diamine FluorideIndication
Dental CariesDrug
Varlilumab