Value of Liquid Potassium Magnesium Citrate in Controlling Hypertension

STU 072012-001

In the DASH (Dietary Approaches to Stop Hypertension) trials, a diet rich in fruits, vegetables, nuts and dairy products, and limited in fat content, was shown to be useful in controlling hypertension. Key components of such a diet are potassium, magnesium and alkali, each of which has been implicated in lowering blood pressure. Whether a liquid formulation of potassium-magnesium citrate will result in equivalent BP effect as the DASH diet is unknown.

2012-09-01

2015-01-01

2015-01-01

Completed

Early phase I

30

Inclusion Criteria: * Patients with pre- or Stage I hypertension, with systolic blood pressure of 120-159 mm and diastolic of 80-99 mm * Age \> 21 years of age Exclusion Criteria: * Diabetes mellitus, * Renal impairment (serum creatinine \> 1.4 mg/dL), * Any heart diseases such as congestive heart failure or sustained arrhythmia, * Chronic NSAID use, * Treatment with diuretics, * Gastroesophageal reflux disease (GERD) requiring treatment with acid reducing agents or antacid more than once a week, * Esophageal-gastric ulcer, * Chronic diarrhea * Hyperkalemia (serum \> 4.6 mmol/L for patients on Angiotensin converting enzyme (ACE) inhibitors or Angiotensin receptor blockers (ARB), serum K \> 5.0 for patient not on ACE inhibitors or ARBs) * Liver function test above upper limit of normal range. * Subjects who require any potassium supplement on a regular basis from any reasons * Pregnancy * History of major depression, bipolar disorder, or schizophrenia * History of substance abuse.

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2023-10-16