Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease

BRONDEL Ass INRA 2011

This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.

2013-10-07

2021-05-03

2021-05-03

Completed

62

For patients : Inclusion Criteria: * Age between 18 and 60 years, * Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference, * Men or women who have provided consent and willing to cooperate. Exclusion Criteria: * Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis. * Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV), * Organ failure (respiratory, heart, or renal failure, neurological disorders), * Intolerance to gluten, * Treatments (other than those used for Crohn's disease) able to interfere with food intake, * Aversion to foods consumed or smelled, * Poor understanding of cognitive tasks required. * Crohn's disease complicated by an abscess or infectious complication * Acute Crohn's disease defined by a CDAI score \> 150 For Controls: Inclusion Criteria: * Adult person * Without follow-up for a chronic pathology * Having given its consent Exclusion Criteria: * Protected adult * Person not affiliated to a social security system * Pregnant or breastfeeding woman * Active smoker * No one who does not speak French * Taking treatment that interferes with taste or acts on the central nervous system

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2024-02-22