Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate

STU 092015-058

Chlorthalidone (CTD) may produce various metabolic disturbances, including hypokalemia, activation of Renin-Angiotensin- Aldosterone (RAA) system, oxidative stress, dyslipidemia, Fibroblast growth factor 23 (FGF23) synthesis, and magnesium depletion. These factors may interact with each other to contribute to the development of insulin resistances and metabolic syndrome. Smaller studies have suggested that Potassium magnesium Citrate (KMgCit) can ameliorate CTD- induced metabolic side effects independent of correction of hypokalemia. This study will tests if KMgCit ameliorates CTD induced metabolic effects independent of correction of hypokalemia.

2015-01-01

2022-11-04

2022-11-04

Completed

61

Inclusion Criteria: • Treated or untreated stage I hypertension Exclusion Criteria: * Diabetes mellitus, * Renal impairment (serum creatinine \> 1.4 mg/dL), * Any heart diseases such as congestive heart failure, sustained arrhythmia, or coronary heart disease, * Chronic regular NSAID use, * Allergy to thiazide diuretics, * Gastro-esophageal reflux disease (GERD) requiring treatment with acid reducing agents or antacid more than once a week, * Esophageal-gastric ulcer or history of gastrointestinal bleeding, * Chronic diarrhea, vomiting, * Excessive sweating, * Unprovoked hypokalemia (serum K \< 3.5 mmol/L) or hyperkalemia (serum K \> 5.3 mmol/L), * Abnormal liver function test (Aspartate transaminase (AST) or Alanine transaminase (ALT) above upper limit of normal range), * Subjects on any potassium supplement on a regular basis for any reason, such as patients with primary aldosteronism, * Pregnancy, * History of major depression, bipolar disorder, or schizophrenia, * History of substance abuse, * Gout, * Metabolic alkalosis, with serum bicarbonate \> 32 meq/L, * Severe dietary salt restriction, less than1/2 spoonful or 50 meq sodium/day. * Patient with Claustrophobia will not have MRI but can still participate in the study without MRI * Metal implants will not have MRI but can still participate in the study without MRI

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2023-10-25