Alzheimer's PET Imaging in Racially/Ethnically Diverse Adults

AAAR8986

The study employs tau positron emission tomography (PET) imaging in a well-characterized multi-racial/ethnic cohort to examine the extent to which tau pathology is associated with cognition, differences in tau pathology across racial/ethnic groups, and the relationship between MRI markers of small-vessel cerebrovascular disease and tau pathology. The study also investigates amyloid-dependent tau spreading.

2019-03-22

2023-07-14

2023-07-14

Completed

Early phase I

145

Inclusion Criteria: * Aged 35 - 85 years * Have either mild cognitive impairment or mild clinical Alzheimer's disease; or have no problem with memory or thinking. * Able to participate in all scheduled evaluations and to complete all required tests and procedures * Considered likely to comply with the study protocol and to have a high probability of completing the study Exclusion Criteria: * Past or present history of a certain brain disease other than mild cognitive impairment or mild clinical Alzheimer's disease. * Certain significant medical conditions. Examples are uncontrolled epilepsy or multiple serious injuries. * Unable to lie still for PET scans. * Radiation exposure for research studies in the last year that would put you past allowable limits if included in this study. * Participation in the last year in a clinical trial for a disease modifying drug for AD unless it can be determined that your received placebo and not active drug. * Conditions that preclude entry into the scanner (e.g. claustrophobia, etc.). * Inability to have a catheter in your vein for the injection of the radioligand (dye). * Currently pregnant or breastfeeding.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'BASIC_SCIENCE', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 145, 'type': 'ACTUAL'}}

2023-09-18