Acipimox Administration Together With Short-Term Exercise Exerts A Co-Feedback of Growth Hormone, Pancreatic Polypeptide, Peptide YY and Leptin on Ghrelin in Young Bulimic Czech Women: A Randomized Study

AZV Grant Agency

This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women. Two groups of participants will receive Acipimox together with exercise versus identical placebo with exercise.

2003-05-06

2007-12-16

2023-12-20

Early phase I

24

Inclusion Criteria: * Patients with a diagnosis of bulimia nervosa * Body mass index (BMI) between 18 and 23 kg/m2 Exclusion Criteria: * History of heart disease * History of bleeding disorders * Subjects with diabetes type 1 or 2, hypo- or hyperthyroidism * Subjects with hepatogastroenteric disease * Pregnant, trying to become pregnant or breast feeding * Patients with other psychiatric diseases

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 24, 'type': 'ESTIMATED'}}

2023-09-05