A Single-arm Clinical Trial Evaluating the Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization in Patients With Pulp Necrosis of Permanent Teeth

Xueli Mao

Dental pulp necrosis is one of the most common pathological conditions that results in tooth loss. However, regeneration of functional dental pulp has proved difficult. Therefore, the investigators conduct a single-arm study to evaluate the efficacy and safety of pulp regeneration induced by SHED mixed with hyaluronic acid polymerization in patients with pulp necrosis of permanent teeth.

2023-09-01

2026-06-30

2026-09-30

Not yet recruiting

30

Inclusion Criteria: * Patients aged 18 to 45 years * Patients with pulp necrosis of a single canal permanent tooth due to trauma or caries * Patients who have signed informed consent Exclusion Criteria: * Patients with pulp necrosis caused by severe trauma to the tooth, such as crown root fracture, tooth root fracture, tooth displacement, etc * Patients with calcification of the apical foramen at the root of the tooth * History of hereditary disorders of abnormal tooth development * Dental occlusal trauma, bruxism, malocclusion * Bad oral habits (sticking out the tongue, biting lips, biting nails, sucking fingers, etc.) * Presence of uncontrollable pathological processes in the oral cavity (presence of acute advanced diseases in the oral cavity) * Malnutrition (serum albumin concentration\<2 g/dl) * Patients with history of other systemic, communicable or hereditary diseases have been diagnosed * Pregnant, nursing, planning to become pregnant * The investigators determined that the patient was not suitable for the study

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 30, 'type': 'ESTIMATED'}}

2023-08-28