Clinical trial
Comparison of Standard Therapy,Peginterferon Alpha-2a + Ribavirin for 48 Weeks VS Peginterferon Alph-2a + Ribavirin + Betaine for 12 Weeks Followed by 36 Weeks Standard Therapy in Untreated Adults With Chronic Hepatitis C Genotype 1
Name
0159-07-FB
Description
The primary purpose of the study is to compare the safety and effectiveness of standard treatment for chronic hepatitis C using peginterferon alpha-2a (Pegasys) and ribavirin (Copegus) to those same medications plus a dietary supplement called betaine when added for the first 12 weeks of treatment.
Peginterferon alpha-2a (Pegasys) and ribavirin (Copegus) are approved by the FDA (Food and Drug Administration) for the treatment of chronic hepatitis C.
Betaine is a dietary supplement and occurs naturally in the body. It is not a medication regulated by the FDA or an approved drug for chronic hepatitis C.
Trial arms
Trial start
2008-04-01
Estimated PCD
2010-03-04
Trial end
2010-03-04
Status
Withdrawn
Treatment
Peginterferon alpha-2a and ribavirin
Peginterferon alpha-2a 180mcg by subcutaneous injection every week and weight based ribavirin, 800 to 1400mg/day by mouth in two divided doses every day for 48 weeks
Arms:
1 Standard Peginterferon alpha-2a plus Rivavirin Therapy
Other names:
Pegasys, Copegus
Peginterferon alpha-2a , ribavirin and betaine
Peginterferon alpha-2a 180mcg given by subcutaneous injection every week plus weight based ribavirin 800 to 1400 mg/day by mouth in divided doses twice a day plus betaine 10 gm dissolved in juice twice a day for twelve weeks followed by peginterferon alpha-2a 180 mcg given by subcutaneous injection every week plus weight based ribavirin 800 to 1400mg/day by mouth in divided doses twice a day for 36 weeks.
Arms:
2 Peginterferon alpha-2a plus Rivavirin Therapy with Betaine for First 12 Weeks
Other names:
Pegasys, Copegas
Primary endpoint
Sustained Viral Response 24 weeks following the end of anti-viral therapy
72 weeks
Eligibility criteria
Inclusion Criteria:
* Subject must be willing to give informed consent and be able to adhere to dose and visit schedules.
* History of chronic hepatitis C as documented by either anti-HCV or HCV RNA positivity.
* Adult subjects 19-70 years of age, of either gender
* Liver biopsy within 3 years prior to the screening 1 visit.
* Compensated liver disease with the following maximum hematologic, biochemical and serologic criteria at the Screening visit (WNL=within normal limits) Hemoglobin \> 12 g/dl for females and \>13 g/dl for males, WBC \> 3000/mm3, Platelets \> 80,000/mm3, Direct Bilirubin - WNL. Indirect bilirubin - WNL, Albumin - WNL, Serum Creatinine - WNL.
* Fasting glucose should be 70 -140 mg/dl, results between 116-140 require a HbA1c \< 8.5%
* TSH - WNL
* Subjects with a history of mild depression may be considered for entry in to this study provided that a pretreatment assessment of the subject's affective status supports that the subject is clinically stable.
* Subjects with a history of substance abuse must have abstained from using the substance for at least one year prior to the Screening visit.
* Antinuclear antibodies (ANA) \< 1:320
* No radiologic evidence of a focal mass suggestive of hepatoma and/or ascites.
Exclusion Criteria:
* Pregnant or nursing subjects. Subjects who intend to become pregnant during the study period. Subjects with partners who intend to become pregnant during the study period.
* History of new hepatitis C exposure within the last 6 months
* Prior treatment for chronic hepatitis C.
* Current or intended use of G-CSF and/or GM-CSF during the stud period is prohibited. Current use of erythropoietin (EPO) is prohibited.
* Suspected hypersensitivity to any interferon product or ribavirin
* Participation in any other clinical trial within 30 days of Screening visit
* Treatment with any investigational drug within 30 days of Screening visit 1.
* Any other cause for liver disease other than CHC.
* Coagulopathies including hemophilia
* Hemoglobinopathies
* G6PD deficiency
* Coinfection with HIV and/or HBV
* Evidence of active or suspected malignancy or a history of malignancy within the last five years (with the exception of adequately treated basal cell carcinoma of the skin).
* Evidence of decompensated liver disease such as history or presence of ascites, bleeding varices or hepatic encephalopathy
* Subjects with organ transplants other than cornea or hair transplant
* Any Known preexisting medical condition, that could interfere with the subject's participation in and completion of the study.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 0, 'type': 'ACTUAL'}}
Updated at
2023-08-15
1 organization
2 products
1 indication
Organization
University of NebraskaIndication
Hepatitis C