Comparison of Fluid Resuscitation in Pediatric Burn Patients Using Crystalloids and With Albumin on Day Two.

260/RC/KEMU

The goal of this comparative, interventional randomized controlled trial is to use albumin during resuscitation in pediatric burn patients on day 2, as it can reduce extravasation of fluids and decrease the overall fluid requirements, along with mortality and maintain circulation. Participants will be divided into 2 groups. Albumin will be administered additionally in group A, while only crystalloids will be used for resuscitation in group B.

2022-01-01

2022-12-18

2023-05-17

Completed

Early phase I

90

Inclusion Criteria: * 25-40%, less than 12 hours old, scald or flame burn patients * Full thickness Exclusion Criteria: * Burns with inhalational injury. * Patients hypersensitive to Albumin. * Deranged renal or hepatic profile. * Patients with known Cardiac or debilitating Congenital anomalies. * Patients with known metabolic disease. * Burns associated with trauma including fractures, head injuries, intra-abdominal bleed etc. * Albumin level lower than 1.8g/dl at time of admission.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2', 'PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 90, 'type': 'ACTUAL'}}

2024-01-25